Literature DB >> 7699419

Cytokine gene expression on glioma cell lines and specimens.

R Yamanaka1, R Tanaka, T Saitoh, S Okoshi.   

Abstract

Expression of the cytokine genes in human glioma cell lines and specimens was studied. Primers for 7 different human cytokine, IL-1 beta, IL-6, IL-8, GM-CSF, TGF-beta 1, TNF-alpha and IFN-gamma were used to analyze messenger RNA transcripts by polymerase chain reaction (PCR). Messenger RNA encoding for IL-1 beta, IL-6, IL-8, GM-CSF and TGF-beta 1 was found to be expressed in some of glioma cell lines. And those showed a proliferative response to IL-1 beta. IL-8 mRNA was found in 2 of 5 low grade gliomas, in 8 of 9 high grade gliomas. TGF-beta 1 mRNA was found in all gliomas, in 1 of 2 normal brains. IL-1 beta mRNA was only found in normal brains. TNF-alpha and IFN-gamma were not found in glioma cell lines and specimens. IL-8 mRNA was apt to be found more frequently among high grade glioma specimens.

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Year:  1994        PMID： 7699419     DOI： 10.1007/bf01063773

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  17 in total

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  16 in total

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Review 6.  STAT3 regulation of glioblastoma pathogenesis.

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Review 7.  Interleukins in glioblastoma pathophysiology: implications for therapy.

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Review 8.  iNOS: a potential therapeutic target for malignant glioma.

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9.  Growth inhibition of human glioma cells modulated by retrovirus gene transfection with antisense IL-8.

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