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Literature DB >> 7698282

A convulsant, 3-mercaptopropionic acid, decreases the level of GABA and GAD in rat pancreatic islets and brain.

J Katoh¹, H Taniguchi, M Ogura, M Kasuga, Y Okada.

Abstract

To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after intraperitoneal administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg. 60 min after the administration of 3-MP, GABA concentration in the hypothalamus, the superior colliculus and the hippocampus of the brain decreased by 20-30% and in the pancreatic islets by 35%. The concentration in the pancreatic acini did not change. Western blotting showed that GAD activity in the pancreatic islets decreased after administration of 3-MP compared to the control. The activity of GAD in the pancreatic islets as well as brain can be modified by a convulsant, in this case 3-MP. These results suggest the properties of GAD may be similar in the pancreatic islets and brain.

Entities: Chemical Disease Gene Species

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Year: 1995 PMID： 7698282 DOI： 10.1007/bf01931099

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

16 in total

1. Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets.

Authors: D S Cram; L D Barnett; J L Joseph; L C Harrison
Journal: Biochem Biophys Res Commun Date: 1991-05-15 Impact factor: 3.575

Review 2. The structural and functional heterogeneity of glutamic acid decarboxylase: a review.

Authors: M G Erlander; A J Tobin
Journal: Neurochem Res Date: 1991-03 Impact factor: 3.996

Review 3. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus.

Authors: M Solimena; P De Camilli
Journal: Trends Neurosci Date: 1991-10 Impact factor: 13.837

4. Simple and easy method for harvesting of a large number of isolated islets and their function.

Authors: Y Hara; H Taniguchi; K Ishihara; K Ejiri; A Tsutou; K Narutaki; S Baba
Journal: Transplant Proc Date: 1989-02 Impact factor: 1.066

5. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

6. Mercaptopropionic acid: a convulsant that inhibits glutamate decarboxylase.

Authors: C Lamar
Journal: J Neurochem Date: 1970-02 Impact factor: 5.372

7. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase.

Authors: S Baekkeskov; H J Aanstoot; S Christgau; A Reetz; M Solimena; M Cascalho; F Folli; H Richter-Olesen; P De Camilli; P D Camilli
Journal: Nature Date: 1990-09-13 Impact factor: 49.962

8. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels.

Authors: P Rorsman; P O Berggren; K Bokvist; H Ericson; H Möhler; C G Ostenson; P A Smith
Journal: Nature Date: 1989-09-21 Impact factor: 49.962

9. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

Authors: D L Kaufman; C R Houser; A J Tobin
Journal: J Neurochem Date: 1991-02 Impact factor: 5.372