Literature DB >> 7694544

Bleomycin increases amikacin and streptomycin resistance in Escherichia coli harboring transposon Tn5.

J Blazquez1, J L Martinez, F Baquero.   

Abstract

The antitumor antibiotic bleomycin acts as a transcriptional inducer of the neo-ble-str operon of the transposon Tn5, increasing the resistance level to streptomycin and amikacin in Tn5-containing Escherichia coli. The mechanism may involve a recA-independent induction mediated by DNA damage.

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Year:  1993        PMID： 7694544      PMCID： PMC188104          DOI： 10.1128/AAC.37.9.1982

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  In vitro gene fusions that join an enzymatically active beta-galactosidase segment to amino-terminal fragments of exogenous proteins: Escherichia coli plasmid vectors for the detection and cloning of translational initiation signals.

Authors:  M J Casadaban; J Chou; S N Cohen
Journal:  J Bacteriol       Date:  1980-08       Impact factor: 3.490

2.  Structural analysis of Tn5.

Authors:  E A Auerswald; G Ludwig; H Schaller
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1981

3.  The functional differences in the inverted repeats of Tn5 are caused by a single base pair nonhomology.

Authors:  S J Rothstein; W S Reznikoff
Journal:  Cell       Date:  1981-01       Impact factor: 41.582

Review 4.  Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.

Authors:  G C Walker
Journal:  Microbiol Rev       Date:  1984-03

Review 5.  Aminoglycoside uptake and mode of action--with special reference to streptomycin and gentamicin. I. Antagonists and mutants.

Authors:  R E Hancock
Journal:  J Antimicrob Chemother       Date:  1981-10       Impact factor: 5.790

6.  Bleomycin-resistance gene derived from the transposon Tn5 confers selective advantage to Escherichia coli K-12.

Authors:  M Blot; J Meyer; W Arber
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

7.  Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

Authors:  F Bolivar; R L Rodriguez; P J Greene; M C Betlach; H L Heyneker; H W Boyer; J H Crosa; S Falkow
Journal:  Gene       Date:  1977       Impact factor: 3.688

8.  Decreased susceptibility to 4'-deoxy-6'-N-methylamikacin (BB-K311) conferred by a mutant plasmid in Escherichia coli.

Authors:  M H Perlin; S A Lerner
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

9.  Tn5 carries a streptomycin resistance determinant downstream from the kanamycin resistance gene.

Authors:  P Putnoky; G B Kiss; I Ott; A Kondorosi
Journal:  Mol Gen Genet       Date:  1983

10.  Transposition of R factor genes to bacteriophage lambda.

Authors:  D E Berg; J Davies; B Allet; J D Rochaix
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205
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  2 in total

1.  Some repair-deficient mutants of Dictyostelium discoideum display enhanced susceptibilities to bleomycin.

Authors:  R A Deering; R B Guyer; L Stevens; T E Watson-Thais
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

Review 2.  Non-canonical mechanisms of antibiotic resistance.

Authors:  J L Martínez; J Blázquez; F Baquero
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994-12       Impact factor: 3.267
  2 in total

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