Literature DB >> 7694398

Cyclosporin A, FK506 and rapamycin: more than just immunosuppression.

J Kunz1, M N Hall.   

Abstract

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.

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Year:  1993        PMID： 7694398     DOI： 10.1016/0968-0004(93)90069-y

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  59 in total

Review 1.  mTOR signaling in cancer cell motility and tumor metastasis.

Authors:  Hongyu Zhou; Shile Huang
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2010       Impact factor: 1.807

2.  CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction.

Authors:  P Nair; R Melarkode; D Rajkumar; E Montero
Journal:  Clin Exp Immunol       Date:  2010-08-19       Impact factor: 4.330

3.  FK506 maturation involves a cytochrome p450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation.

Authors:  Dandan Chen; Lihan Zhang; Bo Pang; Jing Chen; Zhinan Xu; Ikuro Abe; Wen Liu
Journal:  J Bacteriol       Date:  2013-02-22       Impact factor: 3.490

4.  Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling.

Authors:  Michael J Mallory; Samuel J Allon; Jinsong Qiu; Matthew R Gazzara; Iulia Tapescu; Nicole M Martinez; Xiang-Dong Fu; Kristen W Lynch
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

5.  TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

Authors:  S B Helliwell; P Wagner; J Kunz; M Deuter-Reinhard; R Henriquez; M N Hall
Journal:  Mol Biol Cell       Date:  1994-01       Impact factor: 4.138

6.  Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

Authors:  H B Jefferies; C Reinhard; S C Kozma; G Thomas
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

7.  Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase.

Authors:  P Garrett-Engele; B Moilanen; M S Cyert
Journal:  Mol Cell Biol       Date:  1995-08       Impact factor: 4.272

8.  Mitochondrial dysfunction is a primary event in glutamate neurotoxicity.

Authors:  A F Schinder; E C Olson; N C Spitzer; M Montal
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

Review 9.  mTOR signaling: at the crossroads of plasticity, memory and disease.

Authors:  Charles A Hoeffer; Eric Klann
Journal:  Trends Neurosci       Date:  2009-12-04       Impact factor: 13.837

10.  The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae.

Authors:  S Silve; P Leplatois; A Josse; P H Dupuy; C Lanau; M Kaghad; C Dhers; C Picard; A Rahier; M Taton; G Le Fur; D Caput; P Ferrara; G Loison
Journal:  Mol Cell Biol       Date:  1996-06       Impact factor: 4.272
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