Literature DB >> 7694281

Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo.

P M Mathisen1, S Pease, J Garvey, L Hood, C Readhead.   

Abstract

We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon upstream of the usual transcription initiation site. This isoform, embryonic-neonatal MBP (E-MBP), is expressed at the protein level in the embryonic nervous system at a time when other MBP isoforms are not detected. In addition to the central and peripheral nervous systems of the embryo and neonate, the thymus, spleen, and testes also express E-MBP at the protein level. The expression of E-MBP in cell types distinct from the nervous system strongly suggests that this MBP isoform has a role apart from the formation of myelin.

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Year:  1993        PMID： 7694281      PMCID： PMC47726          DOI： 10.1073/pnas.90.21.10125

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Thyroid hormone induction of keratin genes: a two-step activation of gene expression during development.

Authors:  P M Mathisen; L Miller
Journal:  Genes Dev       Date:  1987-12       Impact factor: 11.361

2.  Developmental profile and differential localization of mRNAs of myelin proteins (MBP and PLP) in oligodendrocytes in the brain and in culture.

Authors:  C Shiota; M Miura; K Mikoshiba
Journal:  Brain Res Dev Brain Res       Date:  1989-01-01

3.  Regional expression of myelin protein genes in the developing mouse brain: in situ hybridization studies.

Authors:  A N Verity; A T Campagnoni
Journal:  J Neurosci Res       Date:  1988 Oct-Dec       Impact factor: 4.164

4.  The molecular basis of the sparse fur mouse mutation.

Authors:  G Veres; R A Gibbs; S E Scherer; C T Caskey
Journal:  Science       Date:  1987-07-24       Impact factor: 47.728

5.  A role for platelet-derived growth factor in normal gliogenesis in the central nervous system.

Authors:  W D Richardson; N Pringle; M J Mosley; B Westermark; M Dubois-Dalcq
Journal:  Cell       Date:  1988-04-22       Impact factor: 41.582

6.  Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.

Authors:  A T Campagnoni; T M Pribyl; C W Campagnoni; K Kampf; S Amur-Umarjee; C F Landry; V W Handley; S L Newman; B Garbay; K Kitamura
Journal:  J Biol Chem       Date:  1993-03-05       Impact factor: 5.157

7.  Alternative splicing accounts for the four forms of myelin basic protein.

Authors:  F de Ferra; H Engh; L Hudson; J Kamholz; C Puckett; S Molineaux; R A Lazzarini
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

8.  Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype.

Authors:  C Readhead; B Popko; N Takahashi; H D Shine; R A Saavedra; R L Sidman; L Hood
Journal:  Cell       Date:  1987-02-27       Impact factor: 41.582

9.  Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.

Authors:  S Newman; K Kitamura; A T Campagnoni
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  25 in total

1.  Modulation of myelin basic protein gene expression by acetyl-L-carnitine.

Authors:  Giovanna Traina; Giuseppe Federighi; Monica Macchi; Rodolfo Bernardi; Mauro Durante; Marcello Brunelli
Journal:  Mol Neurobiol       Date:  2011-05-26       Impact factor: 5.590

Review 2.  Immune tolerance in multiple sclerosis.

Authors:  Joan M Goverman
Journal:  Immunol Rev       Date:  2011-05       Impact factor: 12.988

3.  Two proteins bind to a novel motif in the promoter of the myelin basic protein gene from mouse.

Authors:  J Torron; C I Ljubetic; L Huang; K S Kimbro; C Dyer; R A Saavedra
Journal:  J Mol Neurosci       Date:  1997-06       Impact factor: 3.444

4.  Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor.

Authors:  H Waldner; M J Whitters; R A Sobel; M Collins; V K Kuchroo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205

5.  Human neural stem cells induce functional myelination in mice with severe dysmyelination.

Authors:  Nobuko Uchida; Kevin Chen; Monika Dohse; Kelly D Hansen; Justin Dean; Joshua R Buser; Art Riddle; Douglas J Beardsley; Ying Wan; Xi Gong; Thuan Nguyen; Brian J Cummings; Aileen J Anderson; Stanley J Tamaki; Ann Tsukamoto; Irving L Weissman; Steven G Matsumoto; Larry S Sherman; Christopher D Kroenke; Stephen A Back
Journal:  Sci Transl Med       Date:  2012-10-10       Impact factor: 17.956

6.  Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat.

Authors:  L T O'Connor; B D Goetz; J M Kwiecien; K H Delaney; A L Fletch; I D Duncan
Journal:  J Neurosci       Date:  1999-05-01       Impact factor: 6.167

7.  Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC.

Authors:  Emanual Maverakis; Jonathan Beech; David B Stevens; Akio Ametani; Laurent Brossay; Peter van den Elzen; Richard Mendoza; Quoc Thai; Luis H Macias; Doug Ethell; Celia W Campagnoni; Anthony T Campagnoni; Alessandro Sette; Eli E Sercarz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-21       Impact factor: 11.205

Review 8.  The interplay of T cell responses to viral and autoimmune epitopes.

Authors:  E Heber-Katz
Journal:  Immunol Res       Date:  1998       Impact factor: 2.829

9.  Variation in Galr1 expression determines susceptibility to exocitotoxin-induced cell death in mice.

Authors:  S Kong; A Lorenzana; Q Deng; T H McNeill; P E Schauwecker
Journal:  Genes Brain Behav       Date:  2008-07       Impact factor: 3.449

10.  Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination.

Authors:  Erin C Jacobs; Samuel D Reyes; Celia W Campagnoni; M Irene Givogri; Kathy Kampf; Vance Handley; Vilma Spreuer; Robin Fisher; Wendy Macklin; Anthony T Campagnoni
Journal:  ASN Neuro       Date:  2009-09-23       Impact factor: 4.146
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