| Literature DB >> 7692085 |
E S Tackaberry1, J Hamel, Y Larose, B R Brodeur.
Abstract
Experiments were carried out to investigate the ability of rabbit anti-idiotype antibodies (Ab2), directed against an anti-human cytomegalovirus monoclonal antibody (Ab1), to induce neutralizing antibodies specific for the immunodominant glycoprotein B viral complex. Mice immunized with Ab2 produced anti-Ab2 (Ab3) that was both antigen and idiotype specific with regard to Ab1. We conclude that the Ab2 antibodies mimicked a neutralizing epitope and acted as a network antigen for inducing a specific anti-human cytomegalovirus antibody response in this experimental system.Entities:
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Year: 1993 PMID： 7692085 PMCID： PMC238124
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103