| Literature DB >> 7688888 |
Neil MacDonald1, Linda Der, Sharon Allan, Phillip Champion.
Abstract
Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.Entities:
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Year: 1993 PMID： 7688888 DOI： 10.1016/0304-3959(93)90232-E
Source DB: PubMed Journal: Pain ISSN： 0304-3959 Impact factor: 6.961