Literature DB >> 7688513

The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes.

D T Fearon1.   

Abstract

A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.

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Year:  1993        PMID： 7688513     DOI： 10.1016/0952-7915(93)90051-s

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  17 in total

1.  Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.

Authors:  T Miyazaki; U Müller; K S Campbell
Journal:  EMBO J       Date:  1997-07-16       Impact factor: 11.598

2.  Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus.

Authors:  A J Sinclair; P J Farrell
Journal:  J Virol       Date:  1995-09       Impact factor: 5.103

3.  Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

Authors:  H Molina; V M Holers; B Li; Y Fung; S Mariathasan; J Goellner; J Strauss-Schoenberger; R W Karr; D D Chaplin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

4.  Role of peripheral blood mononuclear cell (PBMC) phenotype changes in the pathogenesis of haemorrhagic fever with renal syndrome (HFRS).

Authors:  A Markotić; G Dasić; A Gagro; A Sabioncello; S Rabatić; I Kuzman; R Zgorelec; I Smoljan; I Beus; T A Zupanc; D Dekaris
Journal:  Clin Exp Immunol       Date:  1999-02       Impact factor: 4.330

Review 5.  The B cell antigen receptor complex: mechanisms and implications of tyrosine kinase activation.

Authors:  J Tseng; Y J Lee; B J Eisfelder; M R Clark
Journal:  Immunol Res       Date:  1994       Impact factor: 2.829

6.  CD21-CD23 ligand pair expression in children with allergic asthma.

Authors:  S Rabatić; A Gagro; M Medar-Lasić
Journal:  Clin Exp Immunol       Date:  1993-11       Impact factor: 4.330

7.  The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.

Authors:  Jacqueline M Tarrant; Joanna Groom; Donald Metcalf; Ruili Li; Bette Borobokas; Mark D Wright; David Tarlinton; Lorraine Robb
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

8.  Negative regulation of activation-induced cytidine deaminase in B cells.

Authors:  Taro Muto; Il-mi Okazaki; Shuichi Yamada; Yoshimasa Tanaka; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-13       Impact factor: 11.205

9.  Induction of nitric oxide release by MRC OX-44 (anti-CD53) through a protein kinase C-dependent pathway in rat macrophages.

Authors:  L Boscá; P A Lazo
Journal:  J Exp Med       Date:  1994-04-01       Impact factor: 14.307

10.  The gene coding for the B cell surface protein CD19 is localized on human chromosome 16p11.

Authors:  P Stapleton; Z Kozmik; A Weith; M Busslinger
Journal:  Hum Genet       Date:  1995-02       Impact factor: 4.132
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