Literature DB >> 7687989

Potentiation of metastatic capacity by transforming growth factor-beta 1 gene transfection.

N Ueki1, T Ohkawa, Y Yokoyama, J Maeda, Y Kawai, T Ikeda, Y Amuro, T Hada, K Higashino.   

Abstract

This study was designed to assess whether the excessive secretion of transforming growth factor-beta 1 (TGF-beta 1) by Chinese hamster ovary (CHO) cells transfected with TGF-beta 1 gene may be linked to the development of a metastatic phenotype. We observed large numbers of metastatic colonies in the lungs of nude mice inoculated with the transfected CHO cells. The tumors derived from these transfected cells demonstrated marked angiogenesis. We postulate that the overproduction of TGF-beta 1 by these tumors may participate in the metastatic progression following establishment of angiogenesis at the primary tumor site.

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Year:  1993        PMID： 7687989      PMCID： PMC5919330          DOI： 10.1111/j.1349-7006.1993.tb02017.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  19 in total

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Journal:  Cell       Date:  1987-10-23       Impact factor: 41.582

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  7 in total

1.  Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl) fumagillol (TNP-470) Inhibits Tumor Angiogenesis, Growth and Spontaneous Metastasis of MKL-4 Human Breast Cancer Cells in Female Athymic Nude Mice.

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Journal:  Breast Cancer       Date:  1994-12-30       Impact factor: 4.239

2.  Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells.

Authors:  Cheng-I J Ma; Cyril Martin; Zhong Ma; Anouar Hafiane; Meiou Dai; Jean-Jacques Lebrun; Robert S Kiss
Journal:  J Biol Chem       Date:  2012-03-26       Impact factor: 5.157

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Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-10       Impact factor: 2.673

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Authors:  M Grégoire; B Lieubeau
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Authors:  T Inoue; Y S Chung; M Yashiro; S Nishimura; T Hasuma; S Otani; M Sowa
Journal:  Jpn J Cancer Res       Date:  1997-02

6.  TGF-beta1 genotype and phenotype in breast cancer and their associations with IGFs and patient survival.

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Authors:  H Maeda; S Tsuru; A Shiraishi
Journal:  Jpn J Cancer Res       Date:  1994-11
  7 in total

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