Literature DB >> 2442813

Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.

T A Mustoe, G F Pierce, A Thomason, P Gramates, M B Sporn, T F Deuel.   

Abstract

The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth factor-beta (TGF-beta), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-beta on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-beta. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-beta. TGF-beta is thus a potent pharmacologic agent that can accelerate wound healing in rats.

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Year:  1987        PMID： 2442813     DOI： 10.1126/science.2442813

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  159 in total

1.  Extraction and purification of TGFbeta and its effect on the induction of apoptosis of hepatocytes.

Authors:  X H Si; L J Yang
Journal:  World J Gastroenterol       Date:  2001-08       Impact factor: 5.742

Review 2.  Aging and wound healing.

Authors:  Ankush Gosain; Luisa A DiPietro
Journal:  World J Surg       Date:  2004-02-17       Impact factor: 3.352

Review 3.  Kidney epithelial cells release growth factors in response to extracellular signals.

Authors:  F G Toback; M M Walsh-Reitz; S R Mendley; S Kartha
Journal:  Pediatr Nephrol       Date:  1990-07       Impact factor: 3.714

Review 4.  Growth inhibitors: molecular diversity and roles in cell proliferation.

Authors:  K Miyazaki; T Horio
Journal:  In Vitro Cell Dev Biol       Date:  1989-10

5.  The effects of topical collagen treatment on wound breaking strength and scar cosmesis in rats.

Authors:  Hani Sinno; Meenakshi Malhotra; Justyn Lutfy; Barbara Jardin; Sebastian Winocour; Fadi Brimo; Lorne Beckman; Kevin Watters; Anie Philip; Bruce Williams; Satya Prakash
Journal:  Can J Plast Surg       Date:  2012

6.  Acceleration of tensile strength of incisions treated with EGF and TGF-beta.

Authors:  G L Brown; L J Curtsinger; M White; R O Mitchell; J Pietsch; R Nordquist; A von Fraunhofer; G S Schultz
Journal:  Ann Surg       Date:  1988-12       Impact factor: 12.969

7.  Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia) heals ileoileal anastomosis in the rat.

Authors:  Tihomir Vuksic; Ivan Zoricic; Luka Brcic; Marko Sever; Robert Klicek; Bozo Radic; Vedran Cesarec; Lidija Berkopic; Neike Keller; Alenka Boban Blagaic; Neven Kokic; Ivan Jelic; Juraj Geber; Tomislav Anic; Sven Seiwerth; Predrag Sikiric
Journal:  Surg Today       Date:  2007-08-27       Impact factor: 2.549

8.  Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats.

Authors:  G Westergren-Thorsson; J Hernnäs; B Särnstrand; A Oldberg; D Heinegård; A Malmström
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

9.  Type 1 procollagen as a marker of severity of scarring after sternotomy: effects of topical corticosteroids.

Authors:  Y Riaz; H T Cook; A Wangoo; B Glenville; R J Shaw
Journal:  J Clin Pathol       Date:  1994-10       Impact factor: 3.411

10.  Immunohistochemical evidence of a role for transforming growth factor beta in the pathogenesis of nodular sclerosing Hodgkin's disease.

Authors:  M E Kadin; B A Agnarsson; L R Ellingsworth; S R Newcom
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307
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