BACKGROUND: Chordoma, an uncommon tumor originating from remnants of the notochord, with cutaneous involvement has rarely been reported. OBJECTIVE: Our purpose was to document clinical manifestations, histopathologic features, immunohistochemical findings, treatment, and course of chordoma with cutaneous involvement. METHODS: Pathologically proven cases of chordoma were reviewed retrospectively for cutaneous involvement. Detailed clinical data and histopathologic changes were studied. Skin biopsy specimens were stained for immunohistochemical phenotyping. RESULTS: Of 207 cases of chordoma, 19 had skin involvement: as local recurrences or metastasis in 12, as direct extension of primary tumor in 6, and as a result of distant metastasis from sacrococcygeal chordoma in 1. Local recurrences were frequent, but distant metastasis to various organs, including skin, occurred. CONCLUSION: We propose the term chordoma cutis to describe this condition. In seven patients, cutaneous lesions were detected when the diagnosis of primary chordoma was made.
BACKGROUND:Chordoma, an uncommon tumor originating from remnants of the notochord, with cutaneous involvement has rarely been reported. OBJECTIVE: Our purpose was to document clinical manifestations, histopathologic features, immunohistochemical findings, treatment, and course of chordoma with cutaneous involvement. METHODS: Pathologically proven cases of chordoma were reviewed retrospectively for cutaneous involvement. Detailed clinical data and histopathologic changes were studied. Skin biopsy specimens were stained for immunohistochemical phenotyping. RESULTS: Of 207 cases of chordoma, 19 had skin involvement: as local recurrences or metastasis in 12, as direct extension of primary tumor in 6, and as a result of distant metastasis from sacrococcygeal chordoma in 1. Local recurrences were frequent, but distant metastasis to various organs, including skin, occurred. CONCLUSION: We propose the term chordoma cutis to describe this condition. In seven patients, cutaneous lesions were detected when the diagnosis of primary chordoma was made.
Authors: Conor Fearon; Aurelie Fabre; Eric J Heffernan; Stephen J Skehan; Niall Swan; Michael P Keane; Marcus W Butler Journal: J Thorac Dis Date: 2013-02 Impact factor: 2.895
Authors: Maria C Riesco-Martínez; Lucía Parrilla-Rubio; Ana B Enguita-Valls; Ana M Delgado-Márquez; Sherry A Ruste; Jose-A López-Martín Journal: JAAD Case Rep Date: 2016-02-03
Authors: María Florencia Suarez Conde; Maria Gabriela Vallone; Virginia Mariana González; Felix Alberto Vigovich; Jose Gabriel Casas; Luciano Cermignan; Carlos Arturo Bas; Margarita Larralde Journal: JAAD Case Rep Date: 2019-09-24