Literature DB >> 7685943

Allosteric modulations of the nicotinic acetylcholine receptor.

C Léna1, J P Changeux.   

Abstract

The nicotinic acetylcholine receptor behaves as an allosteric protein with multiple, interconvertible conformations: a resting state, an open channel state and several desensitized states. A variety of pharmacological agents and physiological ligands regulate the transitions between these states when they bind to sites topographically distinct from the acetylcholine binding site. The physiological significance of this type of regulation is discussed and its potential role in the modulation of synaptic efficacy suggested.

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Year:  1993        PMID： 7685943     DOI： 10.1016/0166-2236(93)90150-k

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  35 in total

1.  Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.

Authors:  G P Hess; H Ulrich; H G Breitinger; L Niu; A M Gameiro; C Grewer; S Srivastava; J E Ippolito; S M Lee; V Jayaraman; S E Coombs
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

2.  Brain metabolic effects of acute nicotine.

Authors:  J W Pettegrew; K Panchalingam; R J McClure; J Levine
Journal:  Neurochem Res       Date:  2001-02       Impact factor: 3.996

3.  Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.

Authors:  Nicolas Le Novère; Thomas Grutter; Jean-Pierre Changeux
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

Review 4.  α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.

Authors:  Maryka Quik; Susan Wonnacott
Journal:  Pharmacol Rev       Date:  2011-12       Impact factor: 25.468

Review 5.  Translating laboratory discovery to the clinic: from nicotine and mecamylamine to Tourette's, depression, and beyond.

Authors:  Paul R Sanberg; Cecilia Vindrola-Padros; R Douglas Shytle
Journal:  Physiol Behav       Date:  2012-07-06

Review 6.  Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.

Authors:  Ivet Bahar; Timothy R Lezon; Ahmet Bakan; Indira H Shrivastava
Journal:  Chem Rev       Date:  2010-03-10       Impact factor: 60.622

Review 7.  Receptor-receptor interactions as an integrative mechanism in nerve cells.

Authors:  M Zoli; L F Agnati; P B Hedlund; X M Li; S Ferré; K Fuxe
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

8.  In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.

Authors:  H Ulrich; J E Ippolito; O R Pagán; V A Eterović; R M Hann; H Shi; J T Lis; M E Eldefrawi; G P Hess
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

9.  Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor.

Authors:  J L Galzi; S Bertrand; P J Corringer; J P Changeux; D Bertrand
Journal:  EMBO J       Date:  1996-11-01       Impact factor: 11.598

10.  Isoflurane inhibits nicotinic acetylcholine receptor-mediated 22Na+ influx and muscarinic receptor-evoked cyclic GMP production in cultured bovine adrenal medullary cells.

Authors:  K Minami; N Yanagihara; Y Toyohira; M Tsutsui; A Shigematsu; A Wada; F Izumi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-03       Impact factor: 3.000
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