Literature DB >> 7682831

The effect of toxic doses of cholecalciferol (vitamin D3) on the serum zinc levels in rats.

Y Güven1, S Yildirim, C Kasapoğlu.   

Abstract

Zinc is a trace element important to bone mineralization as well as, in general, nutrition. It is known that cholecalciferol (vitamin D3) affects bone metabolism. In this study, toxic doses of vitamin D3 were injected subcutaneously (25 micrograms/d) to rats for 5 wk. It caused a significant increase in serum zinc levels (p < 0.02). On the other hand, no significant increase was detected in the other groups. Excessive amounts of vitamin D3 caused bone breakdown and increased the levels of zinc in blood.

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Year:  1993        PMID： 7682831     DOI： 10.1007/BF02789403

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  14 in total

1.  Studies on vitamin D3 and the intestinal absorption of calcium and other ions in the rachitic chick.

Authors:  R H Wasserman
Journal:  J Nutr       Date:  1962-05       Impact factor: 4.798

2.  Effect of vitamin D on the utilization of zinc, cadmium and mercury in the chick.

Authors:  N A Worker; B B Migicovsky
Journal:  J Nutr       Date:  1961-10       Impact factor: 4.798

3.  Distribution of zinc in bone tissue.

Authors:  S HAUMONT
Journal:  J Histochem Cytochem       Date:  1961-03       Impact factor: 2.479

4.  Effect of zinc deficiency on collagen metabolism.

Authors:  F Fernandez-Madrid; A S Prasad; D Oberleas
Journal:  J Lab Clin Med       Date:  1971-11

5.  Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic subjects.

Authors:  A S Prasad; D Oberleas; J A Halsted
Journal:  J Lab Clin Med       Date:  1965-09

6.  Human zinc deficiency, endocrine manifestations and response to treatment.

Authors:  H H Sandstead; A S Prasad; A R Schulert; Z Farid; A Miale; S Bassilly; W J Darby
Journal:  Am J Clin Nutr       Date:  1967-05       Impact factor: 7.045

7.  Effect of vitamin D on 65Zn absorption, distribution and turnover in rats.

Authors:  W M Becker; W G Hoekstra
Journal:  J Nutr       Date:  1966-11       Impact factor: 4.798

8.  Protection against zinc deficiency by prior excess dietary zinc in young Japanese quail.

Authors:  B F Harland; M R Spivey Fox; B E Fry
Journal:  J Nutr       Date:  1975-12       Impact factor: 4.798

9.  Effect of toxic doses of cholecalciferol (vitamin D3) on alkaline phosphatase levels in serum and gingival tissues of rats.

Authors:  Y Güven; C Kasapoğlu; S Yildirim; O Gümrü
Journal:  J Nihon Univ Sch Dent       Date:  1990-06

10.  Studies on zinc deficiency: changes in trace elements and enzyme activities in tissues of zinc-deficient rats.

Authors:  A S Prasad; D Oberleas; P Wolf; H P Horwitz
Journal:  J Clin Invest       Date:  1967-04       Impact factor: 14.808
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