Literature DB >> 7680589

5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells.

A R Kooyman1, J A van Hooft, H P Vijverberg.   

Abstract

Effects of 5-hydroxyindole (5-OHi) on 5-HT3 receptor-operated ion current were investigated in voltage-clamped N1E-115 neuroblastoma cells. In the presence of 1 mM 5-OHi, the amplitudes of inward currents induced by the agonists 5-hydroxytryptamine (5-HT), 2-methyl-5-HT and dopamine were enhanced and desensitization of the responses was markedly slowed down. The results indicate that 5-OHi selectively modifies the desensitization of the 5-HT3 receptor-mediated ion current.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7680589      PMCID： PMC1908008          DOI： 10.1111/j.1476-5381.1993.tb12795.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Identification of serotonin 5-HT3 recognition sites in membranes of N1E-115 neuroblastoma cells by radioligand binding.

Authors:  D Hoyer; H C Neijt
Journal:  Mol Pharmacol       Date:  1988-03       Impact factor: 4.436

2.  Kinetics of the membrane current mediated by serotonin 5-HT3 receptors in cultured mouse neuroblastoma cells.

Authors:  H C Neijt; J J Plomp; H P Vijverberg
Journal:  J Physiol       Date:  1989-04       Impact factor: 5.182

3.  The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques.

Authors:  J J Lambert; J A Peters; T G Hales; J Dempster
Journal:  Br J Pharmacol       Date:  1989-05       Impact factor: 8.739

4.  5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line.

Authors:  J L Yakel; M B Jackson
Journal:  Neuron       Date:  1988-09       Impact factor: 17.173

5.  Pharmacological characterization of serotonin 5-HT3 receptor-mediated electrical response in cultured mouse neuroblastoma cells.

Authors:  H C Neijt; I J te Duits; H P Vijverberg
Journal:  Neuropharmacology       Date:  1988-03       Impact factor: 5.250

6.  Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.

Authors:  A V Maricq; A S Peterson; A J Brake; R M Myers; D Julius
Journal:  Science       Date:  1991-10-18       Impact factor: 47.728

7.  Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites).

Authors:  T Amano; E Richelson; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

8.  The dopamine response in mouse neuroblastoma cells is mediated by serotonin 5HT3 receptors.

Authors:  H C Neijt; H P Vijverberg; J Van den Bercken
Journal:  Eur J Pharmacol       Date:  1986-08-15       Impact factor: 4.432

9.  Ion permeation through 5-hydroxytryptamine-gated channels in neuroblastoma N18 cells.

Authors:  J Yang
Journal:  J Gen Physiol       Date:  1990-12       Impact factor: 4.086

10.  Properties of internally perfused, voltage-clamped, isolated nerve cell bodies.

Authors:  K S Lee; N Akaike; A M Brown
Journal:  J Gen Physiol       Date:  1978-05       Impact factor: 4.086
  10 in total
  13 in total

1.  5-hydroxyindole causes convulsions and increases transmitter release in the CA1 region of the rat hippocampus.

Authors:  Guido Mannaioni; Raffaella Carpenedo; Flavio Moroni
Journal:  Br J Pharmacol       Date:  2003-01       Impact factor: 8.739

2.  Diltiazem causes open channel block of recombinant 5-HT3 receptors.

Authors:  M J Gunthorpe; S C Lummis
Journal:  J Physiol       Date:  1999-09-15       Impact factor: 5.182

3.  Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain.

Authors:  M Grilli; L Raiteri; L Patti; M Parodi; F Robino; M Raiteri; M Marchi
Journal:  Br J Pharmacol       Date:  2006-10-03       Impact factor: 8.739

4.  Alcohols potentiate the function of 5-HT3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state.

Authors:  Q Zhou; T A Verdoorn; D M Lovinger
Journal:  J Physiol       Date:  1998-03-01       Impact factor: 5.182

5.  Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the alpha7 nicotinic ACh receptor.

Authors:  M H Selina Mok; James N C Kew
Journal:  J Physiol       Date:  2006-05-11       Impact factor: 5.182

6.  Selection of distinct conformational states of the 5-HT3 receptor by full and partial agonists.

Authors:  J A van Hooft; H P Vijverberg
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

7.  Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor.

Authors:  Andrew D Powell; Gillian Grafton; Alexander Roberts; Shannon Larkin; Nathanael O'Neill; Josephine Palandri; Reka Otvos; Alison J Cooper; Chris Ulens; Nicholas M Barnes
Journal:  Br J Pharmacol       Date:  2016-11-01       Impact factor: 8.739

8.  Direct subunit-dependent multimodal 5-hydroxytryptamine3 receptor antagonism by methadone.

Authors:  Tarek Z Deeb; Douglas Sharp; Tim G Hales
Journal:  Mol Pharmacol       Date:  2009-01-08       Impact factor: 4.436

9.  The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole.

Authors:  Xiang-Qun Hu; David M Lovinger
Journal:  Neuropharmacology       Date:  2008-03-27       Impact factor: 5.250

10.  Electrophysiological consequences of ligand binding to the desensitized 5-HT3 receptor in mammalian NG108-15 cells.

Authors:  J T Bartrup; N R Newberry
Journal:  J Physiol       Date:  1996-02-01       Impact factor: 5.182
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.