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Literature DB >> 3758183

The dopamine response in mouse neuroblastoma cells is mediated by serotonin 5HT3 receptors.

H C Neijt, H P Vijverberg, J Van den Bercken.

Abstract

Serotonin (5HT) and dopamine (DA) induce, in neuroblastoma N1E-115 cells, a transient membrane depolarization associated with an inward current. The half-maximum response is obtained with 2 microM 5HT or 200 microM DA. The maximum response to 5HT is 2-3 times that to DA. The selective 5HT3 receptor antagonists ICS 205-930 and MDL 72222 at nanomolar concentrations block both the 5HT- and the DA-induced response. High concentrations (10 microM) of 5HT2 receptor antagonists are without effect. It is concluded that, in N1E-115 cells, 5HT and DA activate a single population of 5HT3 receptors.

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Year: 1986 PMID： 3758183 DOI： 10.1016/0014-2999(86)90374-2

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

12 in total

1. [3H]ICS 205-930 labels 5-HT3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion.

Authors: D Hoyer; C Waeber; A Karpf; H Neijt; J M Palacios
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1989-10 Impact factor: 3.000

2. Kinetics of the membrane current mediated by serotonin 5-HT3 receptors in cultured mouse neuroblastoma cells.

Authors: H C Neijt; J J Plomp; H P Vijverberg
Journal: J Physiol Date: 1989-04 Impact factor: 5.182

3. PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.

Authors: Erik Svensson; Alex Proekt; Jian Jing; Klaudiusz R Weiss
Journal: J Neurophysiol Date: 2014-04-09 Impact factor: 2.714

4. The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques.

Authors: J J Lambert; J A Peters; T G Hales; J Dempster
Journal: Br J Pharmacol Date: 1989-05 Impact factor: 8.739

5. Characterisation of 5-HT3 recognition sites in membranes of NG 108-15 neuroblastoma-glioma cells with [3H]ICS 205-930.

Authors: H C Neijt; A Karpf; P Schoeffter; G Engel; D Hoyer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-05 Impact factor: 3.000

The dopamine response in mouse neuroblastoma cells is mediated by serotonin 5HT3 receptors.

1. [3H]ICS 205-930 labels 5-HT3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion.

2. Kinetics of the membrane current mediated by serotonin 5-HT3 receptors in cultured mouse neuroblastoma cells.

3. PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.

4. The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques.

5. Characterisation of 5-HT3 recognition sites in membranes of NG 108-15 neuroblastoma-glioma cells with [3H]ICS 205-930.

6. Species variations in 5-HT3 recognition sites labeled by 3H-quipazine in the central nervous system.

7. Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells.

8. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells.

9. Selection of distinct conformational states of the 5-HT3 receptor by full and partial agonists.

10. 5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.