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Literature DB >> 7680503

Agrin and the molecular choreography of synapse formation.

Abstract

High concentrations of neurotransmitter receptors characterize neuromuscular junctions as well as neuron-neuron synapses in the brain and periphery. Synaptic function is critically dependent upon this marshalling of neurotransmitter receptors to the post-synaptic membrane. This review discusses agrin's role in orchestrating the molecular topography of the post-synaptic apparatus at nerve-muscle synapses and the emerging evidence suggesting a role for agrin in synaptogenesis in the brain.

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Year: 1993 PMID： 7680503 DOI： 10.1016/0166-2236(93)90020-m

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

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Cited

13 in total

1. The SEA module: a new extracellular domain associated with O-glycosylation.

Authors: P Bork; L Patthy
Journal: Protein Sci Date: 1995-07 Impact factor: 6.725

2. Subnanosecond polarized fluorescence photobleaching: rotational diffusion of acetylcholine receptors on developing muscle cells.

Authors: Y Yuan; D Axelrod
Journal: Biophys J Date: 1995-08 Impact factor: 4.033

3. Afferent innervation influences the development of dendritic branches and spines via both activity-dependent and non-activity-dependent mechanisms.

Authors: A H Kossel; C V Williams; M Schweizer; S B Kater
Journal: J Neurosci Date: 1997-08-15 Impact factor: 6.167

Agrin and the molecular choreography of synapse formation.

1. The SEA module: a new extracellular domain associated with O-glycosylation.

2. Subnanosecond polarized fluorescence photobleaching: rotational diffusion of acetylcholine receptors on developing muscle cells.

3. Afferent innervation influences the development of dendritic branches and spines via both activity-dependent and non-activity-dependent mechanisms.

4. Neurotrophic factors increase neuregulin expression in embryonic ventral spinal cord neurons.

5. Intracellular calcium regulates agrin-induced acetylcholine receptor clustering.

6. AML1 is expressed in skeletal muscle and is regulated by innervation.

7. Synapsin IIa accelerates functional development of neuromuscular synapses.

8. Aggregation of sodium channels induced by a postnatally upregulated isoform of agrin.

9. Clustering of the acetylcholine receptor by the 43-kD protein: involvement of the zinc finger domain.

10. ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain.