Literature DB >> 7679023

The non-peptide neurokinin1 receptor antagonist, RP 67580, blocks neurogenic plasma extravasation in the dura mater of rats.

S L Shepheard1, D J Williamson, R G Hill, R J Hargreaves.   

Abstract

A non-peptide neurokinin1 (NK1) receptor antagonist, RP 67580, that is selective for the rodent subtype of the NK1 receptor, dose-dependently reduced plasma extravasation in the dura mater produced by electrical stimulation of the trigeminal ganglion in rats, with an ID50 of 0.6 micrograms kg-1. Its enantiomer RP 68651 was some 400 fold less active. The results indicate that neurogenic plasma extravasation within the dura mater is NK1 receptor-mediated and suggest that NK1 receptor antagonists may have a role as antimigraine agents.

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Year:  1993        PMID： 7679023      PMCID： PMC1907730          DOI： 10.1111/j.1476-5381.1993.tb13432.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.

Authors:  I J Beresford; P J Birch; R M Hagan; S J Ireland
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

2.  Ergot alkaloids block neurogenic extravasation in dura mater: proposed action in vascular headaches.

Authors:  K Saito; S Markowitz; M A Moskowitz
Journal:  Ann Neurol       Date:  1988-12       Impact factor: 10.422

3.  The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater.

Authors:  M G Buzzi; M A Moskowitz
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

Review 4.  Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine.

Authors:  M A Moskowitz
Journal:  Trends Pharmacol Sci       Date:  1992-08       Impact factor: 14.819

5.  5-Hydroxytryptamine receptor agonists for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation.

Authors:  M G Buzzi; V Dimitriadou; T C Theoharides; M A Moskowitz
Journal:  Brain Res       Date:  1992-06-26       Impact factor: 3.252
  5 in total
  18 in total

1.  Lack of a role for substance P in the control of dural arterial flow.

Authors:  J Carmody; M Pawlak; K Messlinger
Journal:  Exp Brain Res       Date:  1996-10       Impact factor: 1.972

2.  The role of the A(2A) adenosine receptor subtype in functional hyperaemia in the hindlimb of anaesthetized cats.

Authors:  S M Poucher
Journal:  J Physiol       Date:  1996-04-15       Impact factor: 5.182

3.  Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium.

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Journal:  J Neurosci       Date:  2001-02-01       Impact factor: 6.167

Review 4.  The science of migraine.

Authors:  Rami Burstein; Moshe Jakubowski; Steven D Rauch
Journal:  J Vestib Res       Date:  2011       Impact factor: 2.435

5.  Substance P signaling mediates BMP-dependent heterotopic ossification.

Authors:  Lixin Kan; Vitali Y Lounev; Robert J Pignolo; Lishu Duan; Yijie Liu; Stuart R Stock; Tammy L McGuire; Bao Lu; Norma P Gerard; Eileen M Shore; Frederick S Kaplan; John A Kessler
Journal:  J Cell Biochem       Date:  2011-10       Impact factor: 4.429

6.  Capsaicin-insensitive sensory-efferent meningeal vasodilatation evoked by electrical stimulation of trigeminal nerve fibres in the rat.

Authors:  B Peitl; G Pethô; R Pórszász; J Németh; J Szolcsányi
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

7.  Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580.

Authors:  N M Rupniak; S Boyce; A R Williams; G Cook; J Longmore; G R Seabrook; M Caeser; S D Iversen; R G Hill
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

Review 8.  Animal migraine models for drug development: status and future perspectives.

Authors:  Inger Jansen-Olesen; Peer Tfelt-Hansen; Jes Olesen
Journal:  CNS Drugs       Date:  2013-12       Impact factor: 5.749

9.  Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat.

Authors:  J M Laird; R J Hargreaves; R G Hill
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

10.  Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva.

Authors:  W S Lee; S M Moussaoui; M A Moskowitz
Journal:  Br J Pharmacol       Date:  1994-07       Impact factor: 8.739
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