| Literature DB >> 7678345 |
E H Abraham1, A G Prat, L Gerweck, T Seneveratne, R J Arceci, R Kramer, G Guidotti, H F Cantiello.
Abstract
The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.Entities:
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Year: 1993 PMID： 7678345 PMCID： PMC45650 DOI： 10.1073/pnas.90.1.312
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205