Literature DB >> 1374941

Is the multidrug transporter a flippase?

C F Higgins1, M M Gottesman.   

Abstract

The phenomenon of multidrug resistance is correlated with the presence of a membrane protein, P-glycoprotein, which pumps a wide variety of drugs out of cells thus reducing their toxicity. However, the mechanism of this pumping action remains unclear. In this article, we suggest that several properties of the multidrug transporter may be explained if it acts as a 'flippase' to transport drugs from the inner leaflet of the lipid bilayer to the outer or to the external medium.

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Year:  1992        PMID： 1374941     DOI： 10.1016/0968-0004(92)90419-a

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  151 in total

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8.  P-glycoprotein-ATPase modulation: the molecular mechanisms.

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9.  Understanding transport through pharmacological barriers--are we there yet?

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10.  Proton motive force-driven and ATP-dependent drug extrusion systems in multidrug-resistant Lactococcus lactis.

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