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Literature DB >> 7678298

Antigenic and immunogenic properties of recombinant hepatitis A virus 14S and 70S subviral particles.

J T Stapleton¹, V Raina, P L Winokur, K Walters, D Klinzman, E Rosen, J H McLinden.

Abstract

Hepatitis A virus (HAV) has an immunodominant neutralization antigenic site. By using a panel of monoclonal antibodies targeted against the HAV neutralization antigenic site, it was shown that three epitopes within this site are present on 14S subunits (pentamers of the structural unit). In contrast, two other epitopes within this site are formed upon assembly of 14S subunits into capsids. Thus, the epitopes recognized by these two monoclonal antibodies are formed either by a conformational change in the antigenic site or by the juxtaposition of epitope fragments present on different 14S subunits during assembly of 14S into 70S particles. Both 14S and 70S particles elicited HAV-neutralizing antibodies in mice; thus, these particles may be useful for HAV vaccine development.

Entities: Disease Species

Mesh：

Substances：

Year: 1993 PMID： 7678298 PMCID： PMC237464

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

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13 in total

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Journal: J Virol Date: 2014-02-19 Impact factor: 5.103

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Authors: Lluís Aragonès; Albert Bosch; Rosa M Pintó
Journal: J Virol Date: 2007-12-05 Impact factor: 5.103