Literature DB >> 12620879

Antigenic hepatitis A virus structures may be produced in Escherichia coli.

Glòria Sánchez1, Santiago Caballero, Susana Guix, Albert Bosch, Rosa M Pintó.   

Abstract

The synthesis of 14S pentamers and 70S empty capsids of hepatitis A virus (HAV) has been accomplished by expressing the viral genome for periods of time longer than 4 h in Escherichia coli. HAV pentamers (14S) self-assembled into capsids (70S) in vitro. The antibodies induced by these structures recognized and neutralized HAV.

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Year:  2003        PMID： 12620879      PMCID： PMC150110          DOI： 10.1128/AEM.69.3.1840-1843.2003

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


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Authors:  B Rombaut; A Foriers; A Boeyé
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7.  Synthesis of immunogenic hepatitis A virus particles by recombinant baculoviruses.

Authors:  E Rosen; J T Stapleton; J McLinden
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