Literature DB >> 7672014

The effect of glial cell line-derived neurotrophic factor in fibrin glue on developing dopamine neurons.

H Cheng1, B Hoffer, I Strömberg, D Russell, L Olson.   

Abstract

Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-beta superfamily, promotes the survival, morphological differentiation, and high-affinity dopamine (DA) uptake of cultured nigral DA neurons. In order to test potential methodology for peptide delivery in vivo, GDNF-containing fibrin glue balls (8 micrograms/ball) were incorporated with pieces of fetal ventral mesencephalon (E15) and transplanted into the anterior chambers of sympathetically denervated adult rats. Five weeks after grafting, the numbers of TH-positive neurons and the nerve fiber density were significantly higher in the ventral mesencephalic grafts treated with GDNF-containing glue balls than in those treated with vehicle. In addition, the laminin and GFAP immunoreactivities were similar between the two groups. These data support the concept that GDNF is a potent trophic factor for DA neurons in vivo and suggest that fibrin glue may provide a unique and safe means to permit prolonged delivery of trophic molecules to CNS tissues.

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Year:  1995        PMID： 7672014     DOI： 10.1007/bf00242006

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  33 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

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  4 in total

Review 1.  Fibrin glue as a drug delivery system.

Authors:  Patrick P Spicer; Antonios G Mikos
Journal:  J Control Release       Date:  2010-07-15       Impact factor: 9.776

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Authors:  L Studer; C Spenger; R W Seiler; A Othberg; O Lindvall; P Odin
Journal:  Exp Brain Res       Date:  1996-03       Impact factor: 1.972

Review 3.  The Function of FGFR1 Signalling in the Spinal Cord: Therapeutic Approaches Using FGFR1 Ligands after Spinal Cord Injury.

Authors:  Barbara Haenzi; Lawrence D F Moon
Journal:  Neural Plast       Date:  2017-01-18       Impact factor: 3.599

Review 4.  Tissue Adhesives in Reconstructive and Aesthetic Surgery-Application of Silk Fibroin-Based Biomaterials.

Authors:  Ralf Smeets; Nathalie Tauer; Tobias Vollkommer; Martin Gosau; Anders Henningsen; Philip Hartjen; Leonie Früh; Thomas Beikler; Ewa K Stürmer; Rico Rutkowski; Audrey Laure Céline Grust; Sandra Fuest; Robert Gaudin; Farzaneh Aavani
Journal:  Int J Mol Sci       Date:  2022-07-12       Impact factor: 6.208
  4 in total

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