Literature DB >> 7669575

Microsatellite instability in human testicular germ cell tumours.

R A Huddart1, R Wooster, A Horwich, C S Cooper.   

Abstract

DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.

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Year:  1995        PMID： 7669575      PMCID： PMC2033881          DOI： 10.1038/bjc.1995.387

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  26 in total

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Authors:  J Weissenbach; G Gyapay; C Dib; A Vignal; J Morissette; P Millasseau; G Vaysseix; M Lathrop
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Journal:  Genomics       Date:  1992-06       Impact factor: 5.736

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Authors:  C Kimpton; A Walton; P Gill
Journal:  Hum Mol Genet       Date:  1992-07       Impact factor: 6.150

4.  Tetranucleotide repeat polymorphism in the vWF gene.

Authors:  H K van Amstel; P H Reitsma
Journal:  Nucleic Acids Res       Date:  1990-08-25       Impact factor: 16.971

5.  Microsatellite instability in cancer of the proximal colon.

Authors:  S N Thibodeau; G Bren; D Schaid
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Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

7.  Detection of RAS mutations in archival testicular germ cell tumors by polymerase chain reaction and oligonucleotide hybridization.

Authors:  J W Moul; S M Theune; E H Chang
Journal:  Genes Chromosomes Cancer       Date:  1992-09       Impact factor: 5.006

8.  Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

Authors:  H J Han; A Yanagisawa; Y Kato; J G Park; Y Nakamura
Journal:  Cancer Res       Date:  1993-11-01       Impact factor: 12.701

9.  Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.

Authors:  Y Ionov; M A Peinado; S Malkhosyan; D Shibata; M Perucho
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10.  Detection of preferential NRAS mutations in human male germ cell tumors by the polymerase chain reaction.

Authors:  S Ganguly; V V Murty; F Samaniego; V E Reuter; G J Bosl; R S Chaganti
Journal:  Genes Chromosomes Cancer       Date:  1990-01       Impact factor: 5.006
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  7 in total

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Journal:  Nat Commun       Date:  2015-01-22       Impact factor: 14.919

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7.  Mismatch repair deficiency occurs very rarely in seminomas.

Authors:  David Dum; Stefan Steurer; Ronald Simon; Pia Victoria Zimmermann; Eike Burandt; Till Sebastian Clauditz; Margit Fisch; Michael Rink; Roland Dahlem; Wolfgang Höppner; Henrik Zecha; Ousman Doh; Cord Matthies; Waldemar Wilczak; Guido Sauter; Christoph Fraune
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  7 in total

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