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Literature DB >> 76685

Marker rescue of endogenous cellular genetic information related to the avian leukosis virus gene encoding RNA-directed DNA polymerase.

Abstract

Endogenous cellular genetic information related to the avian leukosis virus gene encoding RNA-directed DNA polymerase was studied, using a marker rescue assay to detect biological activity of subgenomic fragments of virus-related DNAs of uninfected avian cells. Recipient cultures of chicken embryo fibroblasts were treated with sonicated DNA fragments and were infected with a temperature-sensitive mutant of Rous sarcoma virus that encoded a thermolabile DNA polymerase. Wild-type progeny viruses were isolated by marker rescue with fragments of DNA of uninfected chicken, pheasant, quail, and turkey cells. The DNAs of these uninfected avian cells, therefore, appeared to contain endogenous genetic information related to the avian leukosis virus DNA polymerase gene.

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Year: 1978 PMID： 76685 PMCID： PMC525972 DOI： 10.1128/JVI.25.3.788-796.1978

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

40 in total

Marker rescue of endogenous cellular genetic information related to the avian leukosis virus gene encoding RNA-directed DNA polymerase.

1. Recombination between endogenous and exogenous RNA tumor virus genes as analyzed by nucleic acid hybridization.

2. RNA tumor virus specific sequences in nuclear DNA of several avian species.

3. Chicken leukosis virus genome sequences in DNA from normal chick cells and virus-induced bursal lymphomas.

4. An RNA-dependent DNA polymerase, different from the known viral reverse transcriptases, in the chicken system.

5. Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay.

6. Production of unique C-type viruses by chicken cells grown in bromodeoxyuridine.

7. Homology between avian oncornavirus RNAs and DNA from several avian species.

8. Intracellular restriction on the growth of induced subgroup E avian type C viruses in chicken cells.

9. Pheasant virus: new class of ribodeoxyvirus.

10. Assay of noninfectious fragments of DNA of avian leukosis virus-infected cells by marker rescue.

1. Infectious murine leukemia virus from DNA of virus-negative AKR mouse embryo cells.

2. Synthesis and processing of polymerase proteins of wild-type and mutant avian retroviruses.

3. Formation of Rous associated virus-60: origin of the polymerase gene.

4. Mapping of alterations in noninfectious proviruses of spleen necrosis virus.