Literature DB >> 7668292

Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish.

D L Pauls1, J Ott, S M Paul, C R Allen, C S Fann, J P Carulli, K M Falls, C A Bouthillier, T C Gravius, T P Keith.   

Abstract

Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

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Year:  1995        PMID： 7668292      PMCID： PMC1801276     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  27 in total

1.  Update on the search for DNA markers linked to manic-depressive illness in the Old Order Amish.

Authors:  E I Ginns; J A Egeland; C R Allen; D L Pauls; K Falls; T P Keith; S M Paul
Journal:  J Psychiatr Res       Date:  1992-10       Impact factor: 4.791

2.  A critical analysis of data presented in eight studies favouring X-linkage of bipolar illness with special emphasis on formal genetic aspects.

Authors:  J Hebebrand; K Hennighausen
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132

Review 3.  How genetically heterogeneous are the major psychiatric disorders?

Authors:  S H Barondes
Journal:  J Psychiatr Res       Date:  1992-10       Impact factor: 4.791

4.  Allele frequency estimation from data on relatives.

Authors:  M Boehnke
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

5.  The affected-pedigree-member method of linkage analysis.

Authors:  D E Weeks; K Lange
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

6.  Linkage analysis of fifty-seven microsatellite loci to bipolar disorder.

Authors:  P V Gejman; M Martinez; Q Cao; E Friedman; W H Berrettini; L R Goldin; P Koroulakis; C Ames; M A Lerman; E S Gershon
Journal:  Neuropsychopharmacology       Date:  1993-08       Impact factor: 7.853

7.  A microsatellite genetic linkage map of human chromosome 18.

Authors:  R E Straub; M C Speer; Y Luo; K Rojas; J Overhauser; J Ott; T C Gilliam
Journal:  Genomics       Date:  1993-01       Impact factor: 5.736

8.  Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees.

Authors:  M Baron; N F Freimer; N Risch; B Lerer; J R Alexander; R E Straub; S Asokan; K Das; A Peterson; J Amos
Journal:  Nat Genet       Date:  1993-01       Impact factor: 38.330

9.  Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

Authors:  W H Berrettini; T N Ferraro; L R Goldin; D E Weeks; S Detera-Wadleigh; J I Nurnberger; E S Gershon
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

10.  A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

Authors:  H Coon; S Jensen; M Hoff; J Holik; R Plaetke; F Reimherr; P Wender; M Leppert; W Byerley
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025
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  8 in total

1.  Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain.

Authors:  K W Broman; J L Weber
Journal:  Am J Hum Genet       Date:  1999-12       Impact factor: 11.025

2.  A genome-wide search for chromosomal loci linked to mental health wellness in relatives at high risk for bipolar affective disorder among the Old Order Amish.

Authors:  E I Ginns; P St Jean; R A Philibert; M Galdzicka; P Damschroder-Williams; B Thiel; R T Long; L J Ingraham; H Dalwaldi; M A Murray; M Ehlert; S Paul; B G Remortel; A P Patel; M C Anderson; C Shaio; E Lau; I Dymarskaia; B M Martin; B Stubblefield; K M Falls; J P Carulli; T P Keith; C S Fann; L G Lacy; C R Allen; A M Hostetter; R C Elston; N J Schork; J A Egeland; S M Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

3.  Detection of linkage to affective disorders in the catalogued Amish pedigrees: a reply to Pauls et al.

Authors:  E S Gershon; L R Goldin; J A Badner; W H Berrettini
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

4.  Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series.

Authors:  F J McMahon; P J Hopkins; J Xu; M G McInnis; S Shaw; L Cardon; S G Simpson; D F MacKinnon; O C Stine; R Sherrington; D A Meyers; J R DePaulo
Journal:  Am J Hum Genet       Date:  1997-12       Impact factor: 11.025

5.  A susceptibility locus for bipolar affective disorder on chromosome 4q35.

Authors:  L J Adams; P B Mitchell; S L Fielder; A Rosso; J A Donald; P R Schofield
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

6.  No evidence for significant linkage between bipolar affective disorder and chromosome 18 pericentromeric markers in a large series of multiplex extended pedigrees.

Authors:  J A Knowles; P A Rao; T Cox-Matise; J E Loth; G M de Jesus; L Levine; K Das; G K Penchaszadeh; J R Alexander; B Lerer; J Endicott; J Ott; T C Gilliam; M Baron
Journal:  Am J Hum Genet       Date:  1998-04       Impact factor: 11.025

7.  Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.

Authors:  S G Schwab; J Hallmayer; B Lerer; M Albus; M Borrmann; S Hönig; M Strauss; R Segman; D Lichtermann; M Knapp; M Trixler; W Maier; D B Wildenauer
Journal:  Am J Hum Genet       Date:  1998-10       Impact factor: 11.025

8.  Molecular linkage studies of bipolar disorder.

Authors:  W H Berrettini
Journal:  Dialogues Clin Neurosci       Date:  1999-06       Impact factor: 5.986
  8 in total

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