Literature DB >> 7666549

Classical swine fever virus: independent induction of protective immunity by two structural glycoproteins.

M König1, T Lengsfeld, T Pauly, R Stark, H J Thiel.   

Abstract

To study which proteins of classical swine fever virus (CSFV) are able to confer protective immunity in swine, N-terminal autoprotease, viral core protein, and the three structural glycoproteins were expressed via vaccinia virus recombinants (VVR). CSFV proteins synthesized in cells infected with VVR showed migration characteristics on sodium dodecyl sulfate gels identical to those of their respective CSFV counterparts. Apparently authentic dimerization of the recombinant glycoproteins was observed. The glycoproteins E0 and E2 were detected on the surfaces of VVR-infected cells. In protection experiments, swine were immunized with the different VVR, and the generation of humoral immune response was monitored. Only animals vaccinated with VVR expressing E0 and/or E2 resisted a lethal challenge infection with CSFV. Glycoprotein E0 represents a second determinant for the induction of protective immunity against classical swine fever.

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Year:  1995        PMID： 7666549      PMCID： PMC189549     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

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Authors:  T Rümenapf; G Meyers; R Stark; H J Thiel
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5.  Cellular immune response to hog cholera virus (HCV): T cells of immune pigs proliferate in vitro upon stimulation with live HCV, but the E1 envelope glycoprotein is not a major T-cell antigen.

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Journal:  J Virol       Date:  1993-05       Impact factor: 5.103

6.  The protective value of vaccine-induced neutralising antibody titres in swine fever.

Authors:  C Terpstra; G Wensvoort
Journal:  Vet Microbiol       Date:  1988-02       Impact factor: 3.293

7.  Molecular cloning and nucleotide sequence of the genome of hog cholera virus.

Authors:  G Meyers; T Rümenapf; H J Thiel
Journal:  Virology       Date:  1989-08       Impact factor: 3.616

8.  Proteins encoded by bovine viral diarrhea virus: the genomic organization of a pestivirus.

Authors:  M S Collett; R Larson; S K Belzer; E Retzel
Journal:  Virology       Date:  1988-07       Impact factor: 3.616

9.  Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus.

Authors:  M P Cranage; T Kouzarides; A T Bankier; S Satchwell; K Weston; P Tomlinson; B Barrell; H Hart; S E Bell; A C Minson
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Review 10.  The scanning model for translation: an update.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1989-02       Impact factor: 10.539
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  53 in total

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Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

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Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

4.  The carboxy-terminal sequence of the pestivirus glycoprotein E(rns) represents an unusual type of membrane anchor.

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Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

5.  Mutation of cysteine 171 of pestivirus E rns RNase prevents homodimer formation and leads to attenuation of classical swine fever virus.

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Journal:  J Virol       Date:  2009-03-04       Impact factor: 5.103

6.  Prokaryotic expression and purification of highly soluble partial glycoprotein erns of Indian strain of classical Swine Fever virus.

Authors:  A Ahuja; A Sen; R Yogisharadhya; K K Rajak; S B Shivachandra
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7.  A new type of signal peptidase cleavage site identified in an RNA virus polyprotein.

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8.  Thioredoxin 2 Is a Novel E2-Interacting Protein That Inhibits the Replication of Classical Swine Fever Virus.

Authors:  Su Li; Jinghan Wang; Wen-Rui He; Shuo Feng; Yongfeng Li; Xiao Wang; Yajin Liao; Hua-Yang Qin; Lian-Feng Li; Hong Dong; Yuan Sun; Yuzi Luo; Hua-Ji Qiu
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9.  A structural model of pestivirus E(rns) based on disulfide bond connectivity and homology modeling reveals an extremely rare vicinal disulfide.

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Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

10.  Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA.

Authors:  N Ruggli; J D Tratschin; C Mittelholzer; M A Hofmann
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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