Literature DB >> 7665533

Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP.

S C King1, S R Fleming, C Brechtel.   

Abstract

Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.

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Year:  1995        PMID： 7665533      PMCID： PMC177340          DOI： 10.1128/jb.177.18.5381-5382.1995

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  6 in total

1.  Specificity and regulation of gamma-aminobutyrate transport in Escherichia coli.

Authors:  S Kahane; R Levitz; Y S Halpern
Journal:  J Bacteriol       Date:  1978-08       Impact factor: 3.490

2.  Counterflow of galactosides in Escherichia coli.

Authors:  P T Wong; T H Wilson
Journal:  Biochim Biophys Acta       Date:  1970

3.  Selectivity of the Escherichia coli outer membrane porins ompC and ompF.

Authors:  K B Heller; T H Wilson
Journal:  FEBS Lett       Date:  1981-07-06       Impact factor: 4.124

4.  Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene.

Authors:  E Niegemann; A Schulz; K Bartsch
Journal:  Arch Microbiol       Date:  1993       Impact factor: 2.552

5.  Inhibition of growth of Escherichia coli by lactose and other galactosides.

Authors:  D M Wilson; R M Putzrath; T H Wilson
Journal:  Biochim Biophys Acta       Date:  1981-12-07

6.  Functional roles of Glu-269 and Glu-325 within the lactose permease of Escherichia coli.

Authors:  P J Franco; R J Brooker
Journal:  J Biol Chem       Date:  1994-03-11       Impact factor: 5.157
  6 in total
  8 in total

Review 1.  Linkage map of Escherichia coli K-12, edition 10: the traditional map.

Authors:  M K Berlyn
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

2.  Functional sensitivity of polar surfaces on transmembrane helix 8 and cytoplasmic loop 8-9 of the Escherichia coli GABA (4-aminobutyrate) transporter encoded by gabP: mutagenic analysis of a consensus amphipathic region found in transporters from bacteria to mammals.

Authors:  L A Hu; S C King
Journal:  Biochem J       Date:  1998-03-01       Impact factor: 3.857

3.  Identification of the amine-polyamine-choline transporter superfamily 'consensus amphipathic region' as the target for inactivation of the Escherichia coli GABA transporter GabP by thiol modification reagents. Role of Cys-300 in restoring thiol sensitivity to Gabp lacking Cys.

Authors:  L A Hu; S C King
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.857

4.  Membrane topology of the Escherichia coli gamma-aminobutyrate transporter: implications on the topography and mechanism of prokaryotic and eukaryotic transporters from the APC superfamily.

Authors:  L A Hu; S C King
Journal:  Biochem J       Date:  1998-11-15       Impact factor: 3.857

5.  Characterization of a {gamma}-aminobutyric acid transport system of Rhizobium leguminosarum bv. viciae 3841.

Authors:  J P White; J Prell; V K Ramachandran; P S Poole
Journal:  J Bacteriol       Date:  2008-12-19       Impact factor: 3.490

6.  Induction of substrate specificity shifts by placement of alanine insertions within the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.

Authors:  Steven C King; Liaoyuan A Hu; Amy Pugh
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

7.  Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.

Authors:  Steven C King; Lisa Brown-Istvan
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

8.  4-Aminobutyrate (GABA) transporters from the amine-polyamine-choline superfamily: substrate specificity and ligand recognition profile of the 4-aminobutyrate permease from Bacillus subtilis.

Authors:  C E Brechtel; S C King
Journal:  Biochem J       Date:  1998-08-01       Impact factor: 3.857
  8 in total

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