BACKGROUND: Abnormal cerebral anatomical lateralisation has been reported in schizophrenia and may implicate anomalous neurodevelopment in the aetiology of this disease. A popular recent hypothesis has predicted that such disturbances in normal lateralisation should be especially apparent in the morphology of the temporal lobes. METHOD: A temporal cortical region lying in the plane of the Sylvian fissure--known as the planum temporale--exhibits pronounced leftward asymmetry in normal right-handed males. We compared lateralisation of the planum temporale in schizophrenic and control males using MRI surface-rendering morphometry of the supratemporal cortex. RESULTS: Contrary to the lateralisation hypothesis, normal patterns of leftward planum asymmetry were detected in both the schizophrenic and control groups. Schizophrenics and controls also exhibited a predicted symmetry in the bilateral areas of Heschl's gyrus, a supratemporal cortical structure immediately anterior to the planum. CONCLUSION: These data do not support the notion that neurodevelopmental mechanisms of cerebral asymmetry are abnormal in schizophrenia.
BACKGROUND: Abnormal cerebral anatomical lateralisation has been reported in schizophrenia and may implicate anomalous neurodevelopment in the aetiology of this disease. A popular recent hypothesis has predicted that such disturbances in normal lateralisation should be especially apparent in the morphology of the temporal lobes. METHOD: A temporal cortical region lying in the plane of the Sylvian fissure--known as the planum temporale--exhibits pronounced leftward asymmetry in normal right-handed males. We compared lateralisation of the planum temporale in schizophrenic and control males using MRI surface-rendering morphometry of the supratemporal cortex. RESULTS: Contrary to the lateralisation hypothesis, normal patterns of leftward planum asymmetry were detected in both the schizophrenic and control groups. Schizophrenics and controls also exhibited a predicted symmetry in the bilateral areas of Heschl's gyrus, a supratemporal cortical structure immediately anterior to the planum. CONCLUSION: These data do not support the notion that neurodevelopmental mechanisms of cerebral asymmetry are abnormal in schizophrenia.
Authors: R W McCarley; C G Wible; M Frumin; Y Hirayasu; J J Levitt; I A Fischer; M E Shenton Journal: Biol Psychiatry Date: 1999-05-01 Impact factor: 13.382
Authors: Allyssa J Allen; Mélina E Griss; Bradley S Folley; Keith A Hawkins; Godfrey D Pearlson Journal: Schizophr Res Date: 2009-02-15 Impact factor: 4.939
Authors: Y Hirayasu; R W McCarley; D F Salisbury; S Tanaka; J S Kwon; M Frumin; D Snyderman; D Yurgelun-Todd; R Kikinis; F A Jolesz; M E Shenton Journal: Arch Gen Psychiatry Date: 2000-07
Authors: Kiyoto Kasai; Martha E Shenton; Dean F Salisbury; Yoshio Hirayasu; Toshiaki Onitsuka; Magdalena H Spencer; Deborah A Yurgelun-Todd; Ron Kikinis; Ferenc A Jolesz; Robert W McCarley Journal: Arch Gen Psychiatry Date: 2003-08
Authors: John F Smiley; Troy A Hackett; Todd M Preuss; Cynthia Bleiwas; Khadija Figarsky; J John Mann; Gorazd Rosoklija; Daniel C Javitt; Andrew J Dwork Journal: Psychiatry Res Date: 2013-10-19 Impact factor: 3.222