Literature DB >> 7656731

Isolation and characterization of an anticoagulant present in the salivary glands of the bont-legged tick, Hyalomma truncatum.

A M Joubert1, J C Crause, A R Gaspar, F C Clarke, A M Spickett, A W Neitz.   

Abstract

A low molecular mass anticoagulant (17 kDa) was isolated from the salivary glands of prefed female Hyalomma truncatum ticks by means of reverse phase and anion-exchange HPLC. Trypsin digestion and amino acid analysis confirmed the protein nature of the anticoagulant. The inhibitor appears to be uncompetitive with a Ki of 6.9 x 10(-10)M. The target of the anticoagulant is factor Xa at the junction of the extrinsic and intrinsic pathways. This may be crucial for the survival of the tick, making it feasible to investigate the possibility of vaccination with this antihaemostatic against tick feeding. In addition, tick anticoagulants may possibly have therapeutic application in controlling thrombosis.

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Year:  1995        PMID： 7656731     DOI： 10.1007/bf00052548

Source DB:  PubMed          Journal:  Exp Appl Acarol        ISSN： 0168-8162            Impact factor:   2.132


  11 in total

1.  Recombinant hirudin, a new anticoagulant, has no effect on faecal blood loss.

Authors:  B H Meyer; H G Luus; F O Muller; P N Badenhorst; M G Lotter; H J Röthig; H Grötsch; B Rosenkranz
Journal:  Br J Clin Pharmacol       Date:  1992-05       Impact factor: 4.335

2.  Purification and characterization of an anticoagulant from the salivary glands of the ixodid tick Rhipicephalus appendiculatus.

Authors:  M K Limo; W P Voigt; A G Tumbo-Oeri; R M Njogu; O K ole-MoiYoi
Journal:  Exp Parasitol       Date:  1991-05       Impact factor: 2.011

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa.

Authors:  L Waxman; D E Smith; K E Arcuri; G P Vlasuk
Journal:  Science       Date:  1990-05-04       Impact factor: 47.728

5.  Why is uncompetitive inhibition so rare? A possible explanation, with implications for the design of drugs and pesticides.

Authors:  A Cornish-Bowden
Journal:  FEBS Lett       Date:  1986-07-14       Impact factor: 4.124

6.  Isolation of an inhibitor selective for collagen-stimulated platelet aggregation from the soft tick Ornithodoros moubata.

Authors:  L Waxman; T M Connolly
Journal:  J Biol Chem       Date:  1993-03-15       Impact factor: 5.157

7.  Characterization of recombinant tick anticoagulant peptide. A highly selective inhibitor of blood coagulation factor Xa.

Authors:  M P Neeper; L Waxman; D E Smith; C A Schulman; M Sardana; R W Ellis; L W Schaffer; P K Siegl; G P Vlasuk
Journal:  J Biol Chem       Date:  1990-10-15       Impact factor: 5.157

8.  Comparison of the in vivo anticoagulant properties of standard heparin and the highly selective factor Xa inhibitors antistasin and tick anticoagulant peptide (TAP) in a rabbit model of venous thrombosis.

Authors:  G P Vlasuk; D Ramjit; T Fujita; C T Dunwiddie; E M Nutt; D E Smith; R J Shebuski
Journal:  Thromb Haemost       Date:  1991-03-04       Impact factor: 5.249

9.  Tick anticoagulant peptide: kinetic analysis of the recombinant inhibitor with blood coagulation factor Xa.

Authors:  S P Jordan; L Waxman; D E Smith; G P Vlasuk
Journal:  Biochemistry       Date:  1990-12-18       Impact factor: 3.162

10.  Factors V and VII anticoagulant activities in the salivary glands of feeding Dermacentor andersoni ticks.

Authors:  J R Gordon; J R Allen
Journal:  J Parasitol       Date:  1991-02       Impact factor: 1.276
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  10 in total

1.  Reprolysin metalloproteases from Ixodes persulcatus, Rhipicephalus sanguineus and Rhipicephalus microplus ticks.

Authors:  Abid Ali; Lucas Tirloni; Masayoshi Isezaki; Adriana Seixas; Satoru Konnai; Kazuhiko Ohashi; Itabajara da Silva Vaz Junior; Carlos Termignoni
Journal:  Exp Appl Acarol       Date:  2014-04-01       Impact factor: 2.132

2.  Cloning, nucleotide sequence and expression of the gene encoding factor Xa inhibitor from the salivary glands of the tick, Ornithodoros savignyi.

Authors:  A M Joubert; A I Louw; F Joubert; A W Neitz
Journal:  Exp Appl Acarol       Date:  1998-10       Impact factor: 2.132

3.  Thrombin inhibitor from the salivary gland of the camel tick Hyalomma dromedarii.

Authors:  Mahmoud A Ibrahim; Hassan M M Masoud
Journal:  Exp Appl Acarol       Date:  2017-12-19       Impact factor: 2.132

4.  Isolation and characterization of an anticoagulant from the salivary glands of the tick, Ornithodoros savignyi (Acari: Argasidae).

Authors:  A R Gaspar; A M Joubert; J C Crause; A W Neitz
Journal:  Exp Appl Acarol       Date:  1996-10       Impact factor: 2.132

5.  Isolation and properties of two forms of thrombin inhibitor from the nymphs of the camel tick Hyalomma dromedarii (Acari: Ixodidae).

Authors:  M A Ibrahim; A H Ghazy; T Maharem; M Khalil
Journal:  Exp Appl Acarol       Date:  2001       Impact factor: 2.132

6.  An inhibitor of thrombin-stimulated blood platelet aggregation from the salivary glands of the hard tick Amblyomma variegatum (Acari: Ixodidae).

Authors:  Mária Kazimírová; Viera Jancinová; Margita Petríková; Peter Takác; Milan Labuda; Radomír Nosál'
Journal:  Exp Appl Acarol       Date:  2002       Impact factor: 2.132

7.  Identification of anticoagulant activities in the salivary glands of the soft tick, Ornithodoros savignyi.

Authors:  A R Gaspar; J C Crause; A W Neitz
Journal:  Exp Appl Acarol       Date:  1995-02       Impact factor: 2.132

Review 8.  Tick salivary secretion as a source of antihemostatics.

Authors:  Jindrich Chmelar; Eric Calvo; Joao H F Pedra; Ivo M B Francischetti; Michail Kotsyfakis
Journal:  J Proteomics       Date:  2012-04-27       Impact factor: 4.044

Review 9.  Serine Protease Inhibitors in Ticks: An Overview of Their Role in Tick Biology and Tick-Borne Pathogen Transmission.

Authors:  Adrien A Blisnick; Thierry Foulon; Sarah I Bonnet
Journal:  Front Cell Infect Microbiol       Date:  2017-05-22       Impact factor: 5.293

10.  A 24-48 h fed Amblyomma americanum tick saliva immuno-proteome.

Authors:  Željko M Radulović; Tae K Kim; Lindsay M Porter; Sing-Hoi Sze; Lauren Lewis; Albert Mulenga
Journal:  BMC Genomics       Date:  2014-06-24       Impact factor: 3.969
  10 in total

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