Literature DB >> 7651823

Trans-activation and DNA-binding properties of the transcription factor, Sox-18.

B M Hosking1, G E Muscat, P A Koopman, D H Dowhan, T L Dunn.   

Abstract

Sox-18 is a member of the Sox multi-gene family (Sry-related HMG-box gene). We have bacterially expressed this 378 amino acid protein and demonstrated sequence-specific binding to the Sox DNA-binding motif AACAAAG. A distinct 95 amino acid activation domain was mapped in Sox-18 using GAL4-Sox-18 fusions (amino acids 160-225). Furthermore, Sox-18 was capable of trans-activating gene expression through the AACAAA motif. Our results suggest that Sox-18 functions as a classical trans-activator of gene expression.

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Year:  1995        PMID： 7651823      PMCID： PMC307084          DOI： 10.1093/nar/23.14.2626

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  Transcription activation by the adenovirus E1a protein.

Authors:  J W Lillie; M R Green
Journal:  Nature       Date:  1989-03-02       Impact factor: 49.962

2.  The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.

Authors:  M van de Wetering; M Oosterwegel; F Holstege; D Dooyes; R Suijkerbuijk; A Geurts van Kessel; H Clevers
Journal:  J Biol Chem       Date:  1992-04-25       Impact factor: 5.157

3.  Muscle-specific transcriptional activation by MyoD.

Authors:  H Weintraub; V J Dwarki; I Verma; R Davis; S Hollenberg; L Snider; A Lassar; S J Tapscott
Journal:  Genes Dev       Date:  1991-08       Impact factor: 11.361

4.  Sox 15, a novel member of the murine Sox family of HMG box transcription factors.

Authors:  M van de Wetering; H Clevers
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

5.  Seven new members of the Sox gene family expressed during mouse development.

Authors:  E M Wright; B Snopek; P Koopman
Journal:  Nucleic Acids Res       Date:  1993-02-11       Impact factor: 16.971

6.  Ancestry and diversity of the HMG box superfamily.

Authors:  V Laudet; D Stehelin; H Clevers
Journal:  Nucleic Acids Res       Date:  1993-05-25       Impact factor: 16.971

7.  The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.

Authors:  E Wright; M R Hargrave; J Christiansen; L Cooper; J Kun; T Evans; U Gangadharan; A Greenfield; P Koopman
Journal:  Nat Genet       Date:  1995-01       Impact factor: 38.330

8.  LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].

Authors:  A Travis; A Amsterdam; C Belanger; R Grosschedl
Journal:  Genes Dev       Date:  1991-05       Impact factor: 11.361

9.  Male development of chromosomally female mice transgenic for Sry.

Authors:  P Koopman; J Gubbay; N Vivian; P Goodfellow; R Lovell-Badge
Journal:  Nature       Date:  1991-05-09       Impact factor: 49.962

10.  An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.

Authors:  P Denny; S Swift; F Connor; A Ashworth
Journal:  EMBO J       Date:  1992-10       Impact factor: 11.598
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  17 in total

Review 1.  Sry-box (Sox) transcription factors in gastrointestinal physiology and disease.

Authors:  A D Gracz; S T Magness
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-02-03       Impact factor: 4.052

2.  Cloning and characterisation of the Sry-related transcription factor gene Sox8.

Authors:  G E Schepers; M Bullejos; B M Hosking; P Koopman
Journal:  Nucleic Acids Res       Date:  2000-03-15       Impact factor: 16.971

3.  Sox18 preserves the pulmonary endothelial barrier under conditions of increased shear stress.

Authors:  Christine M Gross; Saurabh Aggarwal; Sanjiv Kumar; Jing Tian; Anita Kasa; Natalia Bogatcheva; Sanjeev A Datar; Alexander D Verin; Jeffrey R Fineman; Stephen M Black
Journal:  J Cell Physiol       Date:  2014-11       Impact factor: 6.384

4.  A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene.

Authors:  T Dickmeis; P Mourrain; L Saint-Etienne; N Fischer; P Aanstad; M Clark; U Strähle; F Rosa
Journal:  Genes Dev       Date:  2001-06-15       Impact factor: 11.361

5.  IRE-ABP (insulin response element-A binding protein), an SRY-like protein, inhibits C/EBPalpha (CCAAT/enhancer-binding protein alpha)-stimulated expression of the sex-specific cytochrome P450 2C12 gene.

Authors:  C Buggs; N Nasrin; A Mode; P Tollet; H F Zhao; J A Gustafsson; M Alexander-Bridges
Journal:  Mol Endocrinol       Date:  1998-09

6.  SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.

Authors:  A Murakami; S Ishida; J Thurlow; J M Revest; C Dickson
Journal:  Nucleic Acids Res       Date:  2001-08-15       Impact factor: 16.971

7.  SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene.

Authors:  V Lefebvre; W Huang; V R Harley; P N Goodfellow; B de Crombrugghe
Journal:  Mol Cell Biol       Date:  1997-04       Impact factor: 4.272

8.  Knockdown of SOX12 expression inhibits the proliferation and metastasis of lung cancer cells.

Authors:  Lei Wang; Fengqing Hu; Saie Shen; Haibo Xiao; Guoqing Li; Mingsong Wang; Ju Mei
Journal:  Am J Transl Res       Date:  2017-09-15       Impact factor: 4.060

9.  SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells.

Authors:  Eriko Sumi; Noriyuki Iehara; Haruhiko Akiyama; Takeshi Matsubara; Akira Mima; Hiroshi Kanamori; Atsushi Fukatsu; David J Salant; Toru Kita; Hidenori Arai; Toshio Doi
Journal:  Am J Pathol       Date:  2007-06       Impact factor: 4.307

10.  An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17, FoxC2, and Etv2.

Authors:  Ashley S Robinson; Stefan C Materna; Ralston M Barnes; Sarah De Val; Shan-Mei Xu; Brian L Black
Journal:  Dev Biol       Date:  2014-08-30       Impact factor: 3.582
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