Literature DB >> 7651376

Superoxide dismutase activity of the captopril-iron complex.

D Jay1, A Cuella, E Jay.   

Abstract

With an assay that generates superoxide anion radicals without the intervention of metal ions we investigated the antioxidant properties of captopril, an angiotensin-converting enzyme inhibitor with a sulfhydryl group. Under these conditions, increasing concentrations of the drug were seen not to scavenge O.-2 directly. However, a combination of captopril and iron could bring about the breakdown of the superoxide anion; a result that may help to understand the free radical-scavenging properties of captopril.

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Year:  1995        PMID： 7651376     DOI： 10.1007/bf00926880

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  19 in total

1.  Study of a Fenton type reaction: effect of captopril and chelating reagents.

Authors:  D Jay; A Cuéllar; E G Jay; C García; R Gleason; E Muñoz
Journal:  Arch Biochem Biophys       Date:  1992-11-01       Impact factor: 4.013

2.  Chloroplast manganese and superoxide.

Authors:  J Lumsden; D O Hall
Journal:  Biochem Biophys Res Commun       Date:  1975-05-19       Impact factor: 3.575

Review 3.  How to characterize a biological antioxidant.

Authors:  B Halliwell
Journal:  Free Radic Res Commun       Date:  1990

4.  Factors that influence the deoxyribose oxidation assay for Fenton reaction products.

Authors:  C C Winterbourn
Journal:  Free Radic Biol Med       Date:  1991       Impact factor: 7.376

5.  Reduction of reperfusion arrhythmias in the ischemic isolated rat heart by angiotensin converting enzyme inhibitors: a comparison of captopril, enalapril, and HOE 498.

Authors:  W H van Gilst; P A de Graeff; H Wesseling; C D de Langen
Journal:  J Cardiovasc Pharmacol       Date:  1986 Jul-Aug       Impact factor: 3.105

6.  The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen.

Authors:  M Nishikimi; N Appaji; K Yagi
Journal:  Biochem Biophys Res Commun       Date:  1972-01-31       Impact factor: 3.575

7.  Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor.

Authors:  G Ertl; R A Kloner; R W Alexander; E Braunwald
Journal:  Circulation       Date:  1982-01       Impact factor: 29.690

8.  Direct scavenging of free radicals by captopril, an angiotensin converting enzyme inhibitor.

Authors:  D Bagchi; R Prasad; D K Das
Journal:  Biochem Biophys Res Commun       Date:  1989-01-16       Impact factor: 3.575

9.  Captopril does not scavenge superoxide: captopril prevents O2-. production by chelating copper.

Authors:  D Jay; A Cuéllar; R Zamorano; E Muñoz; R Gleason
Journal:  Arch Biochem Biophys       Date:  1991-11-01       Impact factor: 4.013

10.  Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals?

Authors:  W Westlin; K Mullane
Journal:  Circulation       Date:  1988-06       Impact factor: 29.690
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  3 in total

1.  Angiotensin-converting enzyme inhibitor captopril prevents activation-induced apoptosis by interfering with T cell activation signals.

Authors:  C Odaka; T Mizuochi
Journal:  Clin Exp Immunol       Date:  2000-09       Impact factor: 4.330

2.  Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.

Authors:  Imene Tabbi-Anneni; Jonathan Buchanan; Robert C Cooksey; E Dale Abel
Journal:  Endocrinology       Date:  2008-05-01       Impact factor: 4.736

3.  Ferrous sulphate interacts with captopril.

Authors:  J P Schaefer; Y Tam; B B Hasinoff; S Tawfik; Y Peng; L Reimche; N R Campbell
Journal:  Br J Clin Pharmacol       Date:  1998-10       Impact factor: 4.335
  3 in total

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