OBJECTIVE: To test the hypothesis that methylphenidate reduces thresholds for reward in children with attention-deficit hyperactivity disorder (ADHD). METHOD: A double-blind crossover design was used in which 16 ADHD boys, aged 8 to 13 years, receivedmethylphenidate on one testing occasion and placebo on another. On each occasion, subjects performed a task that required progressively greater numbers of button presses to earn a fixed monetary payoff. RESULTS: The "breaking point" above which the hyperactive child was unwilling to continue with the task was significantly higher during drug than placebo trials. CONCLUSIONS: The results support an assumption that underlies the reward system dysfunction hypothesis of ADHD, and they suggest that reward mechanisms may underlie the therapeutic effects of stimulants observed across a wide range of tasks and settings.
RCT Entities:
OBJECTIVE: To test the hypothesis that methylphenidate reduces thresholds for reward in children with attention-deficit hyperactivity disorder (ADHD). METHOD: A double-blind crossover design was used in which 16 ADHDboys, aged 8 to 13 years, received methylphenidate on one testing occasion and placebo on another. On each occasion, subjects performed a task that required progressively greater numbers of button presses to earn a fixed monetary payoff. RESULTS: The "breaking point" above which the hyperactive child was unwilling to continue with the task was significantly higher during drug than placebo trials. CONCLUSIONS: The results support an assumption that underlies the reward system dysfunction hypothesis of ADHD, and they suggest that reward mechanisms may underlie the therapeutic effects of stimulants observed across a wide range of tasks and settings.
Authors: Elizabeth B Liddle; Chris Hollis; Martin J Batty; Madeleine J Groom; John J Totman; Mario Liotti; Gaia Scerif; Peter F Liddle Journal: J Child Psychol Psychiatry Date: 2010-11-12 Impact factor: 8.982
Authors: Merideth A Addicott; Julia C Schechter; Jeffrey J Sapyta; James P Selig; Scott H Kollins; Margaret D Weiss Journal: Pharmacol Biochem Behav Date: 2019-06-18 Impact factor: 3.533
Authors: Daniel K Campbell-Meiklejohn; Arndis Simonsen; Mads Jensen; Victoria Wohlert; Trine Gjerløff; Jørgen Scheel-Kruger; Arne Møller; Chris D Frith; Andreas Roepstorff Journal: Neuropsychopharmacology Date: 2012-02-08 Impact factor: 7.853
Authors: Annette Conzelmann; Eva Woidich; Ronald F Mucha; Peter Weyers; Mathias Müller; Klaus-Peter Lesch; Christian P Jacob; Paul Pauli Journal: J Neural Transm (Vienna) Date: 2016-02-06 Impact factor: 3.575
Authors: Cynthia J Pietras; Don R Cherek; Scott D Lane; Oleg V Tcheremissine; Joel L Steinberg Journal: Psychopharmacology (Berl) Date: 2003-09-10 Impact factor: 4.530