Literature DB >> 7647953

Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome.

T Sato1, Y Hata, M Yamamoto, H Morita, K Mizuo, H Yamanari, D Saito, T Ohe.   

Abstract

We describe a 17-year-old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased EAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.

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Year:  1995        PMID: 7647953     DOI: 10.1111/j.1540-8167.1995.tb00400.x

Source DB:  PubMed          Journal:  J Cardiovasc Electrophysiol        ISSN: 1045-3873


  8 in total

Review 1.  K(ATP) channel therapeutics at the bedside.

Authors:  A Jahangir; Andre Terzic
Journal:  J Mol Cell Cardiol       Date:  2005-07       Impact factor: 5.000

2.  Nicorandil abolished repolarisation alternans in a patient with idiopathic long QT syndrome.

Authors:  Y Fujimoto; H Morita; K K Fukushima; T Ohe
Journal:  Heart       Date:  1999-11       Impact factor: 5.994

3.  Bilateral thoracoscopic cervical sympathectomy for the treatment of recurrent polymorphic ventricular tachycardia.

Authors:  A J Turley; J Thambyrajah; A A Harcombe
Journal:  Heart       Date:  2005-01       Impact factor: 5.994

Review 4.  Prevention of ventricular arrhythmias in the congenital long QT syndrome.

Authors:  S Viskin; R Fish
Journal:  Curr Cardiol Rep       Date:  2000-11       Impact factor: 2.931

5.  Clinical suppression of bradycardia dependent premature ventricular contractions by the potassium channel opener nicorandil.

Authors:  N Takahashi; M Ito; T Saikawa; M Arita; T Fujino; H Kagiyama; T Fukumoto; T Sakata
Journal:  Heart       Date:  1998-01       Impact factor: 5.994

6.  Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.

Authors:  Marvin G Chang; Enno de Lange; Guillaume Calmettes; Alan Garfinkel; Zhilin Qu; James N Weiss
Journal:  Heart Rhythm       Date:  2012-12-12       Impact factor: 6.343

7.  Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

Authors:  Najah Abi-Gerges; Ben G Small; Chris L Lawrence; Tim G Hammond; Jean-Pierre Valentin; Chris E Pollard
Journal:  Br J Pharmacol       Date:  2004-07-20       Impact factor: 8.739

8.  Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.

Authors:  Sandeep S Hothi; Glyn Thomas; Matthew J Killeen; Andrew A Grace; Christopher L-H Huang
Journal:  Pflugers Arch       Date:  2009-05-09       Impact factor: 3.657

  8 in total

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