Literature DB >> 10525528

Nicorandil abolished repolarisation alternans in a patient with idiopathic long QT syndrome.

Y Fujimoto1, H Morita, K K Fukushima, T Ohe.   

Abstract

A 23 year old woman with idiopathic long QT syndrome had repeated syncopal attacks associated with torsades de pointes. T wave alternans (TWA) was recorded and the QT interval was abnormally prolonged during treadmill exercise test. Monophasic action potential (MAP) alternans also appeared after an abrupt shortening of the cycle length in electrophysiological study. After intravenous administration of nicorandil 6 mg, both TWA and MAP alternans disappeared.

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Year:  1999        PMID： 10525528      PMCID： PMC1760771          DOI： 10.1136/hrt.82.5.e8

Source DB:  PubMed          Journal:  Heart        ISSN： 1355-6037            Impact factor:   5.994


  5 in total

1.  Electrical alternation of the T-wave: clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndrome.

Authors:  P J Schwartz; A Malliani
Journal:  Am Heart J       Date:  1975-01       Impact factor: 4.749

2.  Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long-QT syndrome.

Authors:  W Shimizu; T Kurita; K Matsuo; K Suyama; N Aihara; S Kamakura; J A Towbin; K Shimomura
Journal:  Circulation       Date:  1998-04-28       Impact factor: 29.690

3.  Nicorandil suppresses a hump on the monophasic action potential and torsade de pointes in a patient with idiopathic long QT syndrome.

Authors:  M Chinushi; Y Aizawa; H Furushima; H Inuzuka; K Ojima; A Shibata
Journal:  Jpn Heart J       Date:  1995-07

4.  Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome.

Authors:  T Sato; Y Hata; M Yamamoto; H Morita; K Mizuo; H Yamanari; D Saito; T Ohe
Journal:  J Cardiovasc Electrophysiol       Date:  1995-04

5.  T wave alternans in idiopathic long QT syndrome.

Authors:  W Zareba; A J Moss; S le Cessie; W J Hall
Journal:  J Am Coll Cardiol       Date:  1994-06       Impact factor: 24.094
  5 in total
  5 in total

Review 1.  Prevention of ventricular arrhythmias in the congenital long QT syndrome.

Authors:  S Viskin; R Fish
Journal:  Curr Cardiol Rep       Date:  2000-11       Impact factor: 2.931

2.  Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo.

Authors:  Jürgen Biermann; Kezhong Wu; Katja E Odening; Stefan Asbach; Gideon Koren; Xuwen Peng; Manfred Zehender; Christoph Bode; Michael Brunner
Journal:  Eur J Pharmacol       Date:  2010-10-17       Impact factor: 4.432

Review 3.  Electrical heart disease: Genetic and molecular basis of cardiac arrhythmias in normal structural hearts.

Authors:  David Farwell; Michael H Gollob
Journal:  Can J Cardiol       Date:  2007-08       Impact factor: 5.223

4.  Empirical correlation of triggered activity and spatial and temporal re-entrant substrates with arrhythmogenicity in a murine model for Jervell and Lange-Nielsen syndrome.

Authors:  Sandeep S Hothi; Glyn Thomas; Matthew J Killeen; Andrew A Grace; Christopher L-H Huang
Journal:  Pflugers Arch       Date:  2009-05-09       Impact factor: 3.657

Review 5.  Murine Electrophysiological Models of Cardiac Arrhythmogenesis.

Authors:  Christopher L-H Huang
Journal:  Physiol Rev       Date:  2017-01       Impact factor: 37.312
  5 in total

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