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Literature DB >> 7647236

A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.

R Bertram¹, P Smolen, A Sherman, D Mears, I Atwater, F Martin, B Soria.

Abstract

S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.

Entities: Chemical

Mesh：

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Year: 1995 PMID： 7647236 PMCID： PMC1282142 DOI： 10.1016/S0006-3495(95)80414-5

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

42 in total

Review 1. Inositol phosphates and cell signalling.

Authors: M J Berridge; R F Irvine
Journal: Nature Date: 1989-09-21 Impact factor: 49.962

2. Evidence for two calcium currents in insulin-secreting cells.

Authors: L S Satin; D L Cook
Journal: Pflugers Arch Date: 1988-04 Impact factor: 3.657

3. Electrical pacemaker mechanisms of pancreatic islet cells.

Authors: D L Cook
Journal: Fed Proc Date: 1984-06

4. Muscarinic receptor modulation of glucose-induced electrical activity in mouse pancreatic B-cells.

Authors: R M Santos; E Rojas
Journal: FEBS Lett Date: 1989-06-05 Impact factor: 4.124

5. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.

Authors: H Takemura; A R Hughes; O Thastrup; J W Putney
Journal: J Biol Chem Date: 1989-07-25 Impact factor: 5.157

6. Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilised by high-voltage discharge.

Authors: P M Jones; J Stutchfield; S L Howell
Journal: FEBS Lett Date: 1985-10-21 Impact factor: 4.124

7. The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: studies with a phorbol ester.

Authors: M Bozem; M Nenquin; J C Henquin
Journal: Endocrinology Date: 1987-09 Impact factor: 4.736

8. Lowering of pHi inhibits Ca2+-activated K+ channels in pancreatic B-cells.

Authors: D L Cook; M Ikeuchi; W Y Fujimoto
Journal: Nature Date: 1984 Sep 20-26 Impact factor: 49.962

9. Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx.

Authors: J C Henquin; M C Garcia; M Bozem; M P Hermans; M Nenquin
Journal: Endocrinology Date: 1988-05 Impact factor: 4.736

10. Evidence that muscarinic potentiation of insulin release is initiated by an early transient calcium entry.

Authors: J V Sánchez-Andrés; C Ripoll; B Soria
Journal: FEBS Lett Date: 1988-04-11 Impact factor: 4.124

30 in total

Review 1. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

Authors: L S Satin
Journal: Endocrine Date: 2000-12 Impact factor: 3.633

A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.

Review 1. Inositol phosphates and cell signalling.

2. Evidence for two calcium currents in insulin-secreting cells.

3. Electrical pacemaker mechanisms of pancreatic islet cells.

4. Muscarinic receptor modulation of glucose-induced electrical activity in mouse pancreatic B-cells.

5. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.

6. Effects of Ca2+ and a phorbol ester on insulin secretion from islets of Langerhans permeabilised by high-voltage discharge.

7. The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: studies with a phorbol ester.

8. Lowering of pHi inhibits Ca2+-activated K+ channels in pancreatic B-cells.

9. Muscarinic control of pancreatic B cell function involves sodium-dependent depolarization and calcium influx.

10. Evidence that muscarinic potentiation of insulin release is initiated by an early transient calcium entry.

Review 1. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

2. The phantom burster model for pancreatic beta-cells.

Review 3. Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.

Review 4. Regulation of insulin secretion in islets of Langerhans by Ca(2+)channels.

5. Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic beta-cells.

6. RyR channels and glucose-regulated pancreatic beta-cells.

7. Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets.

8. The endoplasmic reticulum is a glucose-modulated high-affinity sink for Ca2+ in mouse pancreatic beta-cells.

9. Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.

10. A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells.