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Literature DB >> 18239912

RyR channels and glucose-regulated pancreatic beta-cells.

Xuan Zhan¹, Lijian Yang, Ming Yi, Ya Jia.

Abstract

Ryanodine receptor channel model is introduced to a dynamical model of pancreatic beta-cells to discuss the effects of RyR channels and glucose concentration on membrane potential. The results show Ca2+ concentration changes responding to enhance of glucose concentration is more quickly than that of activating RyR channels, and both methods can induce bursting action potential and increase free cytosolic Ca2+ concentration. An interesting finding is that moderate stimulation to RyR channels will result in a kind of "complex bursting", which is more effective in enhancing average Ca2+ concentration and insulin section.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2008 PMID： 18239912 DOI： 10.1007/s00249-008-0269-0

Source DB: PubMed Journal: Eur Biophys J ISSN： 0175-7571 Impact factor: 1.733

48 in total

1. Stochastic properties of Ca(2+) release of inositol 1,4,5-trisphosphate receptor clusters.

Authors: Jian-Wei Shuai; Peter Jung
Journal: Biophys J Date: 2002-07 Impact factor: 4.033

2. A calcium-based phantom bursting model for pancreatic islets.

Authors: Richard Bertram; Arthur Sherman
Journal: Bull Math Biol Date: 2004-09 Impact factor: 1.758

3. Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets.

Authors: R M Santos; L M Rosario; A Nadal; J Garcia-Sancho; B Soria; M Valdeolmillos
Journal: Pflugers Arch Date: 1991-05 Impact factor: 3.657

4. Ryanodine receptor adaptation and Ca2+(-)induced Ca2+ release-dependent Ca2+ oscillations.

Authors: J Keizer; L Levine
Journal: Biophys J Date: 1996-12 Impact factor: 4.033

5. Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism.

Authors: Y X Li; J Rinzel
Journal: J Theor Biol Date: 1994-02-21 Impact factor: 2.691

6. Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells.

Authors: S Takasawa; T Akiyama; K Nata; M Kuroki; A Tohgo; N Noguchi; S Kobayashi; I Kato; T Katada; H Okamoto
Journal: J Biol Chem Date: 1998-01-30 Impact factor: 5.157

RyR channels and glucose-regulated pancreatic beta-cells.

1. Stochastic properties of Ca(2+) release of inositol 1,4,5-trisphosphate receptor clusters.

2. A calcium-based phantom bursting model for pancreatic islets.

3. Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets.

4. Ryanodine receptor adaptation and Ca2+(-)induced Ca2+ release-dependent Ca2+ oscillations.

5. Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism.

6. Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells.

7. Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances.

8. Glucose-induced insulin release depends on functional cooperation between islet cells.

9. Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose.

10. Slow and fast oscillations of cytoplasmic Ca2+ in pancreatic islets correspond to pulsatile insulin release.

Review 1. Electrical bursting, calcium oscillations, and synchronization of pancreatic islets.

2. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells.