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Literature DB >> 7647027

Potassium channel openers: clinical applications in ischemic heart disease--overview of clinical efficacy of nicorandil.

Abstract

Nicorandil is a balanced arterial and venodilator that may also possess cardioprotective properties via its activation of ATP-sensitive potassium channels. It has a number of beneficial hemodynamic effects and has been shown to be effective in treating angina with similar efficacy as the currently available antianginal agents. In addition, it may have useful effects in unstable and variant angina. In this review we examine the hemodynamic effects of nicorandil and discuss the currently available data on its clinical efficacy, both in isolation and in comparison with other agents.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1995 PMID： 7647027 DOI： 10.1007/bf00878470

Source DB: PubMed Journal: Cardiovasc Drugs Ther ISSN： 0920-3206 Impact factor: 3.727

27 in total

1. Acute hemodynamic effects of single-dose nicorandil in coronary artery disease.

Authors: D J Coltart; M Signy
Journal: Am J Cardiol Date: 1989-06-20 Impact factor: 2.778

2. Effect of nicorandil on exercise performance in patients with effort angina: a multicenter trial using a treadmill exercise test.

Authors: K Kato; H Asanoi; C Wakabayashi; S Hosoda; A Shiina; K Hosono; A Kurita; K Seki; K Ishida; A Kuroiwa
Journal: J Cardiovasc Pharmacol Date: 1987 Impact factor: 3.105

3. Coronary vasodilatory action after a single dose of nicorandil.

Authors: H Suryapranata; P W Serruys; P J De Feyter; P D Verdouw; P G Hugenholtz
Journal: Am J Cardiol Date: 1988-02-01 Impact factor: 2.778

4. Effect of a new coronary vasodilator, nicorandil, on variant angina pectoris.

Authors: H Kishida; S Murao
Journal: Clin Pharmacol Ther Date: 1987-08 Impact factor: 6.875

5. Hemodynamic effects of oral nicorandil in congestive heart failure.

Authors: F D Tice; P F Binkley; R J Cody; M L Moeschberger; J S Mohrland; D L Wolf; C V Leier
Journal: Am J Cardiol Date: 1990-06-01 Impact factor: 2.778

6. Comparison of nicorandil and atenolol in stable angina pectoris.

Authors: L O Hughes; E L Rose; A Lahiri; E B Raftery
Journal: Am J Cardiol Date: 1990-09-15 Impact factor: 2.778

7. A double-blind comparison of nicorandil and metoprolol in stable effort angina pectoris.

Authors: S Di Somma; V Liguori; M Petitto; A Carotenuto; D Bokor; O de Divitiis; M de Divitiis
Journal: Cardiovasc Drugs Ther Date: 1993-02 Impact factor: 3.727

8. Antianginal and anti-ischemic efficacy of nicorandil in comparison with isosorbide-5-mononitrate and isosorbide dinitrate: results from two multicenter, double-blind, randomized studies with stable coronary heart disease patients.

Authors: G Döring
Journal: J Cardiovasc Pharmacol Date: 1992 Impact factor: 3.105

9. Comparison of antianginal activity of nicorandil, propranolol and diltiazem with reference to the antianginal mechanism.

Authors: M Kinoshita; K Hashimoto; Y Ohbayashi; T Inoue; H Taguchi; K Mitsunami
Journal: Am J Cardiol Date: 1989-06-20 Impact factor: 2.778

10. Hemodynamic action of nicorandil in chronic congestive heart failure.

Authors: A C Solal; P Jaeger; J Bouthier; J M Juliard; M Dahan; R Gourgon
Journal: Am J Cardiol Date: 1989-06-20 Impact factor: 2.778

9 in total

1. Investigation and management of stable angina: revised guidelines 1998. Joint Working Party of the British Cardiac Society and Royal College of Physicians of London.

Authors: D de Bono
Journal: Heart Date: 1999-05 Impact factor: 5.994

Review 2. K+ channel opening: a new drug principle in cardiovascular medicine.

Authors: J E Nielsen-Kudsk; S Boesgaard; J Aldershvile
Journal: Heart Date: 1996-08 Impact factor: 5.994

3. [Nicorandil: acute hemodynamic effects of 2 different oral doses of a potassium channel opener in patients with coronary heart disease].

Authors: C Bickel; H J Rupprecht; A Tyrtania; J Rörig; J Meyer
Journal: Med Klin (Munich) Date: 1999-02-15

4. Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes.

Authors: K Muraki; A Sasaoka; M Watanabe; Y Imaizumi
Journal: Br J Pharmacol Date: 2001-03 Impact factor: 8.739

Review 5. Nicorandil. An updated review of its use in ischaemic heart disease with emphasis on its cardioprotective effects.

Authors: A Markham; G L Plosker; K L Goa
Journal: Drugs Date: 2000-10 Impact factor: 9.546

Review 6. Management of stable angina.

Authors: A Jain; V Wadehra; A D Timmis
Journal: Postgrad Med J Date: 2003-06 Impact factor: 2.401