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Literature DB >> 7644475

Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF.

G Lazar¹, T Schaal, T Maniatis, H M Goodman.

Abstract

We show that the higher plant Arabidopsis thaliana has a serine-arginine-rich (SR) protein family whose members contain a phosphoepitope shared by the animal SR family of splicing factors. In addition, we report the cloning and characterization of a cDNA encoding a higher-plant SR protein from Arabidopsis, SR1, which has striking sequence and structural homology to the human splicing factor SF2/ASF. Similar to SF2/ASF, the plant SR1 protein promotes splice site switching in mammalian nuclear extracts. A novel feature of the Arabidopsis SR protein is a C-terminal domain containing a high concentration of proline, serine, and lysine residues (PSK domain), a composition reminiscent of histones. This domain includes a putative phosphorylation site for the mitotic kinase cyclin/p34cdc2.

Entities: Chemical

Mesh：

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Year: 1995 PMID： 7644475 PMCID： PMC41207 DOI： 10.1073/pnas.92.17.7672

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

41 in total

1. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

Authors: X D Fu; A Mayeda; T Maniatis; A R Krainer
Journal: Proc Natl Acad Sci U S A Date: 1992-12-01 Impact factor: 11.205

2. Developmental expression of plant snRNAs.

Authors: B A Hanley; M A Schuler
Journal: Nucleic Acids Res Date: 1991-11-25 Impact factor: 16.971

3. A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

Authors: S Michaud; R Reed
Journal: Genes Dev Date: 1993-06 Impact factor: 11.361

7. Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana.

Authors: Zdravko J Lorković; Andrea Barta
Journal: Nucleic Acids Res Date: 2002-02-01 Impact factor: 16.971

8. The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins.

Authors: M Golovkin; A S Reddy
Journal: Plant Cell Date: 1998-10 Impact factor: 11.277

9. Temperature-sensitive splicing in the floral homeotic mutant apetala3-1.

Authors: R W Sablowski; E M Meyerowitz
Journal: Plant Cell Date: 1998-09 Impact factor: 11.277

10. An intragenic suppressor of the Arabidopsis floral organ identity mutant apetala3-1 functions by suppressing defects in splicing.

Authors: Y Yi; T Jack
Journal: Plant Cell Date: 1998-09 Impact factor: 11.277

Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF.

1. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection.

2. Developmental expression of plant snRNAs.

3. A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

4. 3' splice site selection in dicot plant nuclei is position dependent.

5. Human SR proteins and isolation of a cDNA encoding SRp75.

6. Specific commitment of different pre-mRNAs to splicing by single SR proteins.

7. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA.

8. AU-rich intronic elements affect pre-mRNA 5' splice site selection in Drosophila melanogaster.

9. Functional domains of the human splicing factor ASF/SF2.

10. Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains.

Review 1. Sorting out the complexity of SR protein functions.

2. Alternative splicing modulation by a LAMMER kinase impinges on developmental and transcriptome expression.

3. Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis.

Review 4. NMD mechanism and the functions of Upf proteins in plant.

5. Systematic identification of factors involved in post-transcriptional processes in wheat grain.

6. Ectopic expression of atRSZ33 reveals its function in splicing and causes pleiotropic changes in development.

7. Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana.

8. The plant U1 small nuclear ribonucleoprotein particle 70K protein interacts with two novel serine/arginine-rich proteins.

9. Temperature-sensitive splicing in the floral homeotic mutant apetala3-1.

10. An intragenic suppressor of the Arabidopsis floral organ identity mutant apetala3-1 functions by suppressing defects in splicing.