Literature DB >> 7643715

Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains.

J K Belknap1, J S Mogil, M L Helms, S P Richards, L A O'Toole, S E Bergeson, K J Buck.   

Abstract

A quantitative trait locus (QTL) was detected and mapped to proximal chromosome 10 near the markers Mpmv5 and D10Mit51 with a strong influence on morphine-induced analgesia in the BXD recombinant inbred (RI) strains and in an F2 cross (B6D2F2) between the BXD progenitor strains, C57BL/6 and DBA/2. A LOD score of 3.9 (p < .00002) was seen for analgesia using the hot plate assay. Naloxone Bmax was also associated with this chromosome region in BXD RI mice. The mu opioid receptor gene (Oprm) has recently been mapped to this same chromosome region. The observation that several morphine-related traits and naloxone Bmax appear to be partly determined by this presumed single locus is consistent with the hypothesis that the mu opioid receptor gene, or one of its modulators, is the basis for the QTL.

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Year:  1995        PMID： 7643715     DOI： 10.1016/0024-3205(95)02040-p

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  25 in total

1.  The genetics of pain and analgesia in laboratory animals.

Authors:  William R Lariviere; Jeffrey S Mogil
Journal:  Methods Mol Biol       Date:  2010

2.  Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice.

Authors:  J S Mogil; S P Richards; L A O'Toole; M L Helms; S R Mitchell; B Kest; J K Belknap
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

Review 3.  Mu opioids and their receptors: evolution of a concept.

Authors:  Gavril W Pasternak; Ying-Xian Pan
Journal:  Pharmacol Rev       Date:  2013-09-27       Impact factor: 25.468

4.  Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice.

Authors:  T J Phillips; M G Huson; C S McKinnon
Journal:  J Neurosci       Date:  1998-04-15       Impact factor: 6.167

5.  Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes.

Authors:  Paula L Hoffman; Beth Bennett; Laura M Saba; Sanjiv V Bhave; Phyllis J Carosone-Link; Cheryl K Hornbaker; Katerina J Kechris; Robert W Williams; Boris Tabakoff
Journal:  Addict Biol       Date:  2010-11-04       Impact factor: 4.280

Review 6.  The genetic mediation of individual differences in sensitivity to pain and its inhibition.

Authors:  J S Mogil
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 7.  The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses.

Authors:  G R Uhl; I Sora; Z Wang
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

8.  Qualitative differences between C57BL/6J and DBA/2J mice in morphine potentiation of brain stimulation reward and intravenous self-administration.

Authors:  Greg I Elmer; Jeanne O Pieper; Lindsey R Hamilton; Roy A Wise
Journal:  Psychopharmacology (Berl)       Date:  2009-12-15       Impact factor: 4.530

9.  Identification of candidate genes and gene networks specifically associated with analgesic tolerance to morphine.

Authors:  Jenica D Tapocik; Noah Letwin; Cheryl L Mayo; Bryan Frank; Troung Luu; Ovokeraye Achinike; Carrie House; Russell Williams; Greg I Elmer; Norman H Lee
Journal:  J Neurosci       Date:  2009-04-22       Impact factor: 6.167

10.  Mapping of a quantitative trait locus for morphine withdrawal severity.

Authors:  Benjamin Kest; Christina A Palmese; Aaron Juni; Elissa J Chesler; Jeffrey S Mogil
Journal:  Mamm Genome       Date:  2004-08       Impact factor: 2.957
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