Literature DB >> 7642464

P-glycoprotein in adult solid tumors. Expression and prognostic significance.

J C Leighton1, L J Goldstein.   

Abstract

Several potential mechanisms of chemotherapy resistance have been identified in adult solid tumors. The multidrug resistance (MDR) phenotype is one mechanism by which tumors may simultaneously develop resistance to multiple chemotherapeutic agents and is associated with P-glycoprotein expression. In this article, the authors examine the literature and summarize the various techniques used to measure MDR1 gene expression, patterns of expression in adult solid tumors.

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Year:  1995        PMID： 7642464

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  12 in total

1.  Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.

Authors:  Albert A De Vera; Pranav Gupta; Zining Lei; Dan Liao; Silpa Narayanan; Qiuxu Teng; Sandra E Reznik; Zhe-Sheng Chen
Journal:  Cancer Lett       Date:  2018-11-01       Impact factor: 8.679

Review 2.  Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.

Authors:  Lara Milane; Shanthi Ganesh; Shruti Shah; Zhen-Feng Duan; Mansoor Amiji
Journal:  J Control Release       Date:  2011-04-08       Impact factor: 9.776

3.  Different modalities of intercellular membrane exchanges mediate cell-to-cell p-glycoprotein transfers in MCF-7 breast cancer cells.

Authors:  Jennifer Pasquier; Ludovic Galas; Céline Boulangé-Lecomte; Damien Rioult; Florence Bultelle; Pierre Magal; Glenn Webb; Frank Le Foll
Journal:  J Biol Chem       Date:  2012-01-06       Impact factor: 5.157

4.  Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells.

Authors:  Lara Milane; Zhenfeng Duan; Mansoor Amiji
Journal:  Mol Pharm       Date:  2010-11-24       Impact factor: 4.939

5.  Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.

Authors:  Yi-Jun Wang; Yun-Kai Zhang; Guan-Nan Zhang; Sweilem B Al Rihani; Meng-Ning Wei; Pranav Gupta; Xiao-Yu Zhang; Suneet Shukla; Suresh V Ambudkar; Amal Kaddoumi; Zhi Shi; Zhe-Sheng Chen
Journal:  Cancer Lett       Date:  2017-03-14       Impact factor: 8.679

6.  Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer.

Authors:  Lara Milane; Zhen-feng Duan; Mansoor Amiji
Journal:  Nanomedicine       Date:  2011-01-08       Impact factor: 5.307

Review 7.  Multi-functional nanocarriers to overcome tumor drug resistance.

Authors:  Lara S Jabr-Milane; Lilian E van Vlerken; Sunita Yadav; Mansoor M Amiji
Journal:  Cancer Treat Rev       Date:  2008-06-05       Impact factor: 12.111

Review 8.  Polymer-mediated gene therapy: Recent advances and merging of delivery techniques.

Authors:  Janelle W Salameh; Le Zhou; Sarah M Ward; Cristiam F Santa Chalarca; Todd Emrick; Marxa L Figueiredo
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2019-12-02

9.  Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning.

Authors:  Lara Milane; Zhenfeng Duan; Mansoor Amiji
Journal:  Cancer Cell Int       Date:  2011-02-14       Impact factor: 5.722

Review 10.  Synergistic Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Microenvironment and Cancer Cells.

Authors:  Jingnan Xu; Zhuo Song; Qiujun Guo; Jie Li
Journal:  Biomed Res Int       Date:  2016-03-02       Impact factor: 3.411
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