Janelle W Salameh1, Le Zhou2, Sarah M Ward2, Cristiam F Santa Chalarca2, Todd Emrick2, Marxa L Figueiredo3. 1. The Weldon School of Biomedical Engineering and the Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, Indiana. 2. Polymer Science and Engineering Department, University of Massachusetts, Amherst, Massachusetts. 3. Department of Basic Medical Sciences and the Interdisciplinary Biomedical Sciences Program, Purdue University, West Lafayette, Indiana.
Abstract
The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in synthetic polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability to carry both therapeutic cargo and targeting moieties. The combination of synthetic gene carrying constructs with advanced delivery techniques promises new therapeutic options for treating and curing genetic disorders. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for their safety and efficacy. This study will feature progress in syntheticn>an class="Chemical">polymers as nonviral vectors, which benefit from their chemical versatility, biocompatibility, and ability to carry both therapeutic cargo and targeting moieties. The combination of synthetic gene carrying constructs with advanced delivery techniques promises new therapeutic options for treating and curing genetic disorders. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
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