Literature DB >> 7637478

Thromboprophylaxis with low-molecular-weight heparin in outpatients with plaster-cast immobilisation of the leg.

H J Kock1, K P Schmit-Neuerburg, J Hanke, G Rudofsky, H Hirche.   

Abstract

Deep-vein thrombosis is common after plaster-cast immobilisation for traumatic injury. We did a randomised prospective study of the effect of low-molecular-weight heparin on the incidence of deep-vein thrombosis in patients with minor injuries treated with plaster-cast immobilisation of the leg. A control group (n = 163) received no prophylaxis, the prophylaxis group received low-molecular-weight heparin once daily (n = 176). The incidence of deep-vein thrombosis in the prophylaxis group was 0% (one tailed p < 0.006) vs 4.3% in the control group. No severe side-effects of low-molecular-weight heparin were observed. Thromboprophylaxis with low-molecular-weight heparin once daily is effective in reducing the risk of deep-vein thrombosis in outpatients with plaster-cast immobilisation of the leg.

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Year:  1995        PMID： 7637478     DOI： 10.1016/s0140-6736(95)91320-3

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  25 in total

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Review 3.  Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Prophylaxis of venous thromboembolism in patients with lower limb plaster cast immobilisation.

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5.  Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluation.

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Review 7.  Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization.

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9.  Insufficient Evidence for Routine Use of Thromboprophylaxis in Ambulatory Patients with an Isolated Lower Leg Injury Requiring Immobilization: Results of a Meta-Analysis.

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10.  Risk factors for pulmonary embolism in an Irish patient cohort.

Authors:  S Timmons; R Liston; H Kelly
Journal:  Ir J Med Sci       Date:  2004 Apr-Jun       Impact factor: 1.568
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