Literature DB >> 7637036

Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr.

V Planelles1, F Bachelerie, J B Jowett, A Haislip, Y Xie, P Banooni, T Masuda, I S Chen.   

Abstract

We investigated the fate of human immunodeficiency virus type 1 (HIV-1) viral DNA in infected peripheral blood lymphocytes and immortalized T-cell lines by using a replication-defective HIV-1. We observed that integrated HIV-1 DNA and viral gene expression decrease over time. A frameshift mutation in vpr resulted in maintenance of the HIV-1 provirus and stable persistence of viral expression. Transfection of vpr together with the neomycin resistance gene in the absence of other viral genes decreased the formation of geneticin-resistant colonies, indicating either a cytotoxic or a cytostatic effect upon cells. Therefore, maintenance of HIV-1 infection within an infected proliferating population is due to two competing processes, the rate of viral spread and the degree of cell growth inhibition and/or death induced by Vpr.

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Year:  1995        PMID： 7637036      PMCID： PMC189467     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  39 in total

1.  Identification of HIV-1 vpr product and function.

Authors:  E A Cohen; E F Terwilliger; Y Jalinoos; J Proulx; J G Sodroski; W A Haseltine
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1990

2.  Mutational analysis of the human immunodeficiency virus vpr open reading frame.

Authors:  K Ogawa; R Shibata; T Kiyomasu; I Higuchi; Y Kishida; A Ishimoto; A Adachi
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

3.  HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.

Authors:  B A Larder; G Darby; D D Richman
Journal:  Science       Date:  1989-03-31       Impact factor: 47.728

4.  Molecular characterization of human immunodeficiency virus from Zaire: nucleotide sequence analysis identifies conserved and variable domains in the envelope gene.

Authors:  A Srinivasan; R Anand; D York; P Ranganathan; P Feorino; G Schochetman; J Curran; V S Kalyanaraman; P A Luciw; R Sanchez-Pescador
Journal:  Gene       Date:  1987       Impact factor: 3.688

5.  The DNA provirus hypothesis.

Authors:  H M Temin
Journal:  Science       Date:  1976-06-11       Impact factor: 47.728

6.  High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients.

Authors:  S Pang; Y Koyanagi; S Miles; C Wiley; H V Vinters; I S Chen
Journal:  Nature       Date:  1990-01-04       Impact factor: 49.962

7.  The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

Authors:  N K Heinzinger; M I Bukrinsky; S A Haggerty; A M Ragland; V Kewalramani; M A Lee; H E Gendelman; L Ratner; M Stevenson; M Emerman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

8.  Firefly luciferase gene: structure and expression in mammalian cells.

Authors:  J R de Wet; K V Wood; M DeLuca; D R Helinski; S Subramani
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

9.  New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors.

Authors:  J P Dougherty; R Wisniewski; S L Yang; B W Rhode; H M Temin
Journal:  J Virol       Date:  1989-07       Impact factor: 5.103

10.  Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.

Authors:  Y Koyanagi; S Miles; R T Mitsuyasu; J E Merrill; H V Vinters; I S Chen
Journal:  Science       Date:  1987-05-15       Impact factor: 47.728
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  47 in total

1.  Reservoir expansion by T-cell proliferation may be another barrier to curing HIV infection.

Authors:  Michelle Kim; Robert F Siliciano
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-09       Impact factor: 11.205

2.  Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.

Authors:  Y Kawano; Y Tanaka; N Misawa; R Tanaka; J I Kira; T Kimura; M Fukushi; K Sano; T Goto; M Nakai; T Kobayashi; N Yamamoto; Y Koyanagi
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

3.  Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 genome.

Authors:  Snehlata Tripathi; Binay Chaubey; Beverly E Barton; Virendra N Pandey
Journal:  Virology       Date:  2007-02-21       Impact factor: 3.616

4.  Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells.

Authors:  Dimitrios N Vatakis; Gregory Bristol; Thomas A Wilkinson; Samson A Chow; Jerome A Zack
Journal:  J Virol       Date:  2007-01-17       Impact factor: 5.103

5.  HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate.

Authors:  Dorota Piekna-Przybylska; Kavyasri Nagumotu; Danielle M Reid; Sanjay B Maggirwar
Journal:  J Neurovirol       Date:  2018-11-06       Impact factor: 2.643

6.  Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.

Authors:  T Masuda; V Planelles; P Krogstad; I S Chen
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

7.  Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins.

Authors:  Kei Sato; Jun Aoki; Naoko Misawa; Eriko Daikoku; Kouichi Sano; Yuetsu Tanaka; Yoshio Koyanagi
Journal:  J Virol       Date:  2007-11-07       Impact factor: 5.103

8.  High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G.

Authors:  R K Akkina; R M Walton; M L Chen; Q X Li; V Planelles; I S Chen
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

9.  Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control.

Authors:  S R Bartz; M E Rogel; M Emerman
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

10.  Vpr-induced cell cycle arrest is conserved among primate lentiviruses.

Authors:  V Planelles; J B Jowett; Q X Li; Y Xie; B Hahn; I S Chen
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103
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