Literature DB >> 7635210

Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material.

J Swain1, J M Gutteridge.   

Abstract

Low density lipoproteins are highly sensitive to oxidation by copper salts, and such peroxidation is accompanied by macrophage scavenger receptor recognition. This study shows that fresh human atherosclerotic material (aneurysms and endarterectomies) can contain detectable amounts of redox active iron and copper that is chelatable from tissue homogenates. Such material is often prooxidant towards lipid peroxidation and deoxyribose degradation. Aneurysms and endarterectomies contain ferroxidase 1 activities, whereas only in aneurysms could caeruloplasmin be immunologically detected. Ferroxidase 2 activity, characteristic of a copper-oxidised lipoprotein complex, could not, however, be detected in any of the atherosclerotic samples. A third ferroxidase activity, attributable to xanthine oxidase, was present in several aneurysms and endarterectomies.

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Year:  1995        PMID: 7635210     DOI: 10.1016/0014-5793(95)00726-p

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  21 in total

1.  Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfaces.

Authors:  C K Mukhopadhyay; B Mazumder; P F Lindley; P L Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

2.  Serum antioxidant status among young, middle-aged and elderly people before and after antioxidant rich diet.

Authors:  E Limberaki; Ph Eleftheriou; E Vagdatli; V Kostoglou; Ch Petrou
Journal:  Hippokratia       Date:  2012-04       Impact factor: 0.471

3.  Effect of 6-month caloric restriction on Cu bound to ceruloplasmin in adult overweight subjects.

Authors:  Francesco Piacenza; Marco Malavolta; Andrea Basso; Laura Costarelli; Robertina Giacconi; Eric Ravussin; Leanne M Redman; Eugenio Mocchegiani
Journal:  J Nutr Biochem       Date:  2015-05-06       Impact factor: 6.048

4.  Cu2+ -induced low density lipoprotein peroxidation is dependent on the initial O2 concentration: an O2 consumption study.

Authors:  J K Lodge; M G Traber; P J Sadler
Journal:  Lipids       Date:  2000-10       Impact factor: 1.880

5.  Iron overload diminishes atherosclerosis in apoE-deficient mice.

Authors:  E A Kirk; J W Heinecke; R C LeBoeuf
Journal:  J Clin Invest       Date:  2001-06       Impact factor: 14.808

6.  Role of endogenous ceruloplasmin in low density lipoprotein oxidation by human U937 monocytic cells.

Authors:  E Ehrenwald; P L Fox
Journal:  J Clin Invest       Date:  1996-02-01       Impact factor: 14.808

Review 7.  Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer.

Authors:  S M Hadi; M F Ullah; A S Azmi; A Ahmad; U Shamim; H Zubair; H Y Khan
Journal:  Pharm Res       Date:  2010-01-30       Impact factor: 4.200

Review 8.  Antioxidants in health and disease.

Authors:  I S Young; J V Woodside
Journal:  J Clin Pathol       Date:  2001-03       Impact factor: 3.411

9.  In vivo atherosclerotic plaque characterization using magnetic susceptibility distinguishes symptom-producing plaques.

Authors:  Subha V Raman; Marshall W Winner; Tam Tran; Murugesan Velayutham; Orlando P Simonetti; Peter B Baker; John Olesik; Beth McCarthy; Amy K Ferketich; Jay L Zweier
Journal:  JACC Cardiovasc Imaging       Date:  2008-01

10.  Protective action on human LDL against oxidation and glycation by four organosulfur compounds derived from garlic.

Authors:  Chu-Chyn Ou; Shyh-Ming Tsao; Ming-Cheng Lin; Mei-Chin Yin
Journal:  Lipids       Date:  2003-03       Impact factor: 1.880

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