Literature DB >> 7634088

Crystal structure of the pleckstrin homology domain from dynamin.

D Timm1, K Salim, I Gout, L Guruprasad, M Waterfield, T Blundell.   

Abstract

The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.

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Year:  1994        PMID： 7634088     DOI： 10.1038/nsb1194-782

Source DB:  PubMed          Journal:  Nat Struct Biol        ISSN： 1072-8368


  23 in total

1.  A corkscrew model for dynamin constriction.

Authors:  Jason A Mears; Pampa Ray; Jenny E Hinshaw
Journal:  Structure       Date:  2007-10       Impact factor: 5.006

Review 2.  Building a fission machine--structural insights into dynamin assembly and activation.

Authors:  Joshua S Chappie; Fred Dyda
Journal:  J Cell Sci       Date:  2013-06-18       Impact factor: 5.285

3.  Molecular cloning of an Arabidopsis cDNA encoding a dynamin-like protein that is localized to plastids.

Authors:  S G Kang; J B Jin; H L Piao; K T Pih; H J Jang; J H Lim; I Hwang
Journal:  Plant Mol Biol       Date:  1998-10       Impact factor: 4.076

4.  Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells.

Authors:  C R Artalejo; M A Lemmon; J Schlessinger; H C Palfrey
Journal:  EMBO J       Date:  1997-04-01       Impact factor: 11.598

5.  Common membrane trafficking defects of disease-associated dynamin 2 mutations.

Authors:  Ya-Wen Liu; Vasyl Lukiyanchuk; Sandra L Schmid
Journal:  Traffic       Date:  2011-08-05       Impact factor: 6.215

6.  The crystal structure of dynamin.

Authors:  Marijn G J Ford; Simon Jenni; Jodi Nunnari
Journal:  Nature       Date:  2011-09-18       Impact factor: 49.962

7.  Crystal structure of nucleotide-free dynamin.

Authors:  Katja Faelber; York Posor; Song Gao; Martin Held; Yvette Roske; Dennis Schulze; Volker Haucke; Frank Noé; Oliver Daumke
Journal:  Nature       Date:  2011-09-18       Impact factor: 49.962

8.  Structural similarity between the pleckstrin homology domain and verotoxin: the problem of measuring and evaluating structural similarity.

Authors:  C A Orengo; M B Swindells; A D Michie; M J Zvelebil; P C Driscoll; M D Waterfield; J M Thornton
Journal:  Protein Sci       Date:  1995-10       Impact factor: 6.725

9.  Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

Authors:  M A Lemmon; K M Ferguson; R O'Brien; P B Sigler; J Schlessinger
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

10.  Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain.

Authors:  Qingping Xu; Alex Bateman; Robert D Finn; Polat Abdubek; Tamara Astakhova; Herbert L Axelrod; Constantina Bakolitsa; Dennis Carlton; Connie Chen; Hsiu-Ju Chiu; Michelle Chiu; Thomas Clayton; Debanu Das; Marc C Deller; Lian Duan; Kyle Ellrott; Dustin Ernst; Carol L Farr; Julie Feuerhelm; Joanna C Grant; Anna Grzechnik; Gye Won Han; Lukasz Jaroszewski; Kevin K Jin; Heath E Klock; Mark W Knuth; Piotr Kozbial; S Sri Krishna; Abhinav Kumar; David Marciano; Daniel McMullan; Mitchell D Miller; Andrew T Morse; Edward Nigoghossian; Amanda Nopakun; Linda Okach; Christina Puckett; Ron Reyes; Christopher L Rife; Natasha Sefcovic; Henry J Tien; Christine B Trame; Henry van den Bedem; Dana Weekes; Tiffany Wooten; Keith O Hodgson; John Wooley; Marc-André Elsliger; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Journal:  J Mol Biol       Date:  2009-11-10       Impact factor: 5.469
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