Literature DB >> 7630396

Protein molecules as computational elements in living cells.

D Bray1.   

Abstract

Many proteins in living cells appear to have as their primary function the transfer and processing of information, rather than the chemical transformation of metabolic intermediates or the building of cellular structures. Such proteins are functionally linked through allosteric or other mechanisms into biochemical 'circuits' that perform a variety of simple computational tasks including amplification, integration and information storage.

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Year:  1995        PMID: 7630396     DOI: 10.1038/376307a0

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  131 in total

1.  Gene regulatory networks generating the phenomena of additivity, dominance and epistasis.

Authors:  S W Omholt; E Plahte; L Oyehaug; K Xiang
Journal:  Genetics       Date:  2000-06       Impact factor: 4.562

2.  Engineering aspects of enzymatic signal transduction: photoreceptors in the retina.

Authors:  P B Detwiler; S Ramanathan; A Sengupta; B I Shraiman
Journal:  Biophys J       Date:  2000-12       Impact factor: 4.033

3.  Multi-stage regulation, a key to reliable adaptive biochemical pathways.

Authors:  G Almogy; L Stone; N Ben-Tal
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

4.  Fluctuations and slow variables in genetic networks.

Authors:  R Bundschuh; F Hayot; C Jayaprakash
Journal:  Biophys J       Date:  2003-03       Impact factor: 4.033

Review 5.  Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry.

Authors:  Peter J Kennelly
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

6.  Signal Perception and Transduction: The Origin of the Phenotype.

Authors:  A. J. Trewavas; R. Malho
Journal:  Plant Cell       Date:  1997-07       Impact factor: 11.277

7.  Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways.

Authors:  Upinder S Bhalla
Journal:  Biophys J       Date:  2002-08       Impact factor: 4.033

8.  Structure and function of the feed-forward loop network motif.

Authors:  S Mangan; U Alon
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-06       Impact factor: 11.205

9.  A biophysical model of synaptic delay learning and temporal pattern recognition in a cerebellar Purkinje cell.

Authors:  Volker Steuber; David Willshaw
Journal:  J Comput Neurosci       Date:  2004 Sep-Oct       Impact factor: 1.621

10.  Boolean logic functions of a synthetic peptide network.

Authors:  Gonen Ashkenasy; M Reza Ghadiri
Journal:  J Am Chem Soc       Date:  2004-09-15       Impact factor: 15.419

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