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Literature DB >> 7624316

Cloning and expression of two brain-specific inwardly rectifying potassium channels.

D S Bredt¹, T L Wang, N A Cohen, W B Guggino, S H Snyder.

Abstract

We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[gamma-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.

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Year: 1995 PMID： 7624316 PMCID： PMC41407 DOI： 10.1073/pnas.92.15.6753

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

34 in total

1. Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.

Authors: P Rorsman; G Trube
Journal: Pflugers Arch Date: 1985-12 Impact factor: 3.657

2. Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.

Authors: Z Lu; R MacKinnon
Journal: Nature Date: 1994-09-15 Impact factor: 49.962

3. Cloning and expression of a family of inward rectifier potassium channels.

Authors: C T Bond; M Pessia; X M Xia; A Lagrutta; M P Kavanaugh; J P Adelman
Journal: Receptors Channels Date: 1994

4. Gating of inwardly rectifying K+ channels localized to a single negatively charged residue.

Authors: B A Wible; M Taglialatela; E Ficker; A M Brown
Journal: Nature Date: 1994-09-15 Impact factor: 49.962

5. Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

Authors: F Périer; C M Radeke; C A Vandenberg
Journal: Proc Natl Acad Sci U S A Date: 1994-06-21 Impact factor: 11.205

6. Intracellular ATP directly blocks K+ channels in pancreatic B-cells.

Authors: D L Cook; C N Hales
Journal: Nature Date: 1984 Sep 20-26 Impact factor: 49.962

7. A novel gamma-aminobutyric acid receptor subunit (rho 2) cloned from human retina forms bicuculline-insensitive homooligomeric receptors in Xenopus oocytes.

Authors: T L Wang; W B Guggino; G R Cutting
Journal: J Neurosci Date: 1994-11 Impact factor: 6.167

8. The sulphonylurea receptor may be an ATP-sensitive potassium channel.

Authors: N C Sturgess; M L Ashford; D L Cook; C N Hales
Journal: Lancet Date: 1985-08-31 Impact factor: 79.321

9. Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells.

Authors: F M Ashcroft; D E Harrison; S J Ashcroft
Journal: Nature Date: 1984 Nov 29-Dec 5 Impact factor: 49.962

10. Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart.

Authors: B Sakmann; A Noma; W Trautwein
Journal: Nature Date: 1983 May 19-25 Impact factor: 49.962

18 in total

1. Secondary structure, membrane localization, and coassembly within phospholipid membranes of synthetic segments derived from the N- and C-termini regions of the ROMK1 K+ channel.

Authors: I Ben-Efraim; Y Shai
Journal: Protein Sci Date: 1996-11 Impact factor: 6.725

2. IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain.

Authors: C Karschin; E Dissmann; W Stühmer; A Karschin
Journal: J Neurosci Date: 1996-06-01 Impact factor: 6.167

3. KATP channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit.

Authors: P Drain; L Li; J Wang
Journal: Proc Natl Acad Sci U S A Date: 1998-11-10 Impact factor: 11.205

4. Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.

Authors: C Töpert; F Döring; E Wischmeyer; C Karschin; J Brockhaus; K Ballanyi; C Derst; A Karschin
Journal: J Neurosci Date: 1998-06-01 Impact factor: 6.167

5. Opposite effects of pH on open-state probability and single channel conductance of kir4.1 channels.

Authors: Z Yang; C Jiang
Journal: J Physiol Date: 1999-11-01 Impact factor: 5.182

6. Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina.

Authors: P Kofuji; P Ceelen; K R Zahs; L W Surbeck; H A Lester; E A Newman
Journal: J Neurosci Date: 2000-08-01 Impact factor: 6.167