Literature DB >> 7623781

Thyroid hormone inhibits fatty acid synthase gene transcription in chicken liver.

K Kameda1.   

Abstract

The effect of triiodothyronine (T3) on regulation of fatty acid synthase in chicken liver was investigated. In hypothyroid animals, enzyme activity was about one half of that in euthyroid animals. T3 treatment increased the enzyme activity in hypothyroid animals. There is little difference in both the mRNA concentration and the transcription rate between euthyroid and hypothyroid animals. T3 treatment markedly decreased both the mRNA concentration and the transcription rate in euthyroid and hypothyroid animals. These results suggested that T3 maintained the normal level of enzyme expression primarily by stimulating the post-transcriptional step, while the transcription of the gene was inhibited by hyperthyroidism.

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Year:  1995        PMID： 7623781     DOI： 10.1007/bf00944388

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  16 in total

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Authors:  K Kameda; A G Goodridge
Journal:  J Biol Chem       Date:  1991-01-05       Impact factor: 5.157

2.  Inducible binding of a factor to the c-fos enhancer.

Authors:  R Prywes; R G Roeder
Journal:  Cell       Date:  1986-12-05       Impact factor: 41.582

3.  Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of fatty acid synthase in rat liver.

Authors:  A Katsurada; N Iritani; H Fukuda; Y Matsumura; N Nishimoto; T Noguchi; T Tanaka
Journal:  Eur J Biochem       Date:  1990-06-20

4.  Regulation of the activity of acetyl coenzyme A carboxylase by palmitoyl coenzyme A and citrate.

Authors:  A G Goodridge
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

5.  Hypothalamic-pituitary somatotropic function in prepubertal hypothyroid rats: effect of growth hormone replacement therapy.

Authors:  V De Gennaro Colonna; G Bertola; C B Coco; M Bifano; D Cocchi; A Maggi; E E Müller
Journal:  Proc Soc Exp Biol Med       Date:  1991-04

6.  Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect.

Authors:  S R Stapleton; D A Mitchell; L M Salati; A G Goodridge
Journal:  J Biol Chem       Date:  1990-10-25       Impact factor: 5.157

7.  Molecular cloning and sequencing of DNA complementary to chicken liver fatty acid synthase mRNA.

Authors:  Z Y Yuan; W Liu; G G Hammes
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

8.  Hormonal regulation of lipogenic enzymes in chick embryo hepatocytes in culture. Expression of the fatty acid synthase gene is regulated at both translational and pretranslational steps.

Authors:  S B Wilson; D W Back; S M Morris; J Swierczynski; A G Goodridge
Journal:  J Biol Chem       Date:  1986-11-15       Impact factor: 5.157

9.  Delineation of positive and negative control elements within the promoter region of the murine leukemia inhibitory factor (LIF) gene.

Authors:  J Stahl; N M Gough
Journal:  Cytokine       Date:  1993-07       Impact factor: 3.861

10.  Triiodothyronine regulation of multiple rat hepatic genes: requirement for ongoing protein synthesis.

Authors:  P S Hamblin; A Santos; N C Wong; H L Schwartz; J H Oppenheimer
Journal:  Mol Endocrinol       Date:  1987-06
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  1 in total

1.  Effects of citalopram on dopamine D2 receptor expression in the rat brain striatum.

Authors:  K Kameda; I Kusumi; K Suzuki; J Miura; Y Sasaki; T Koyama
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  1 in total

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