Literature DB >> 76225

Misleading response of malignant gastric ulcers to cimetidine.

R H Taylor, N Menzies-Gow, D Lovell, S J La Brooy, J J Misiewicz.   

Abstract

Four patients who apparently had benign gastric ulcer (G.U.) were treated with cimetidine. The ulcers healed and their symptoms disappeared. However, when cimetidine was stopped the symptoms recurred. Intramucosal cancer was found only at histopathological examination of the resected stomachs in two of the four patients, and in all the cases malignancy had not been detected by the initial serial biopsies and brush cytology. Relief of symptoms of malignant gastric ulcers by cimetidine may delay diagnosis and appropriae treatment.

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Year:  1978        PMID: 76225     DOI: 10.1016/s0140-6736(78)90799-7

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  20 in total

1.  Proton pump inhibitors may mask early gastric cancer. Dyspeptic patients over 45 should undergo endoscopy before these drugs are started.

Authors:  S M Griffin; S A Raimes
Journal:  BMJ       Date:  1998-12-12

2.  Early gastric cancer in clinical practice.

Authors:  T C Simmons; D R Henderson; F Gletten; C Scott; C Miller
Journal:  J Natl Med Assoc       Date:  1988-05       Impact factor: 1.798

Review 3.  Review of general surgery 1978.

Authors:  H Ellis
Journal:  Postgrad Med J       Date:  1979       Impact factor: 2.401

Review 4.  An update on histamine receptors and the gastrointestinal tract.

Authors:  B I Hirschowitz
Journal:  Dig Dis Sci       Date:  1985-10       Impact factor: 3.199

5.  Improving the detection rate of early gastric cancer requires more than open access gastroscopy: a five year study.

Authors:  Z Suvakovic; M G Bramble; R Jones; C Wilson; N Idle; J Ryott
Journal:  Gut       Date:  1997-09       Impact factor: 23.059

6.  Does cimetidine cause gastric cancer?

Authors:  R Downing; J Black
Journal:  Br Med J (Clin Res Ed)       Date:  1981-05-09

7.  Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy.

Authors:  A G Morgan; W A McAdam; C Pacsoo; A Darnborough
Journal:  Gut       Date:  1982-06       Impact factor: 23.059

8.  Time-dependent morphologic change in depressed-type early gastric cancer.

Authors:  Jong Pil Im; Sang Gyun Kim; Joo Sung Kim; Hyun Chae Jung; In Sung Song
Journal:  Surg Endosc       Date:  2009-03-19       Impact factor: 4.584

9.  Use of cimetidine and other peptic ulcer drugs in Denmark 1977-1990 with analysis of the risk of gastric cancer among cimetidine users.

Authors:  H Møller; A Nissen; J Mosbech
Journal:  Gut       Date:  1992-09       Impact factor: 23.059

10.  Gastrointestinal lymphoma and sarcoma. A case for aggressive search and destroy.

Authors:  R B Adkins; H W Scott; J L Sawyers
Journal:  Ann Surg       Date:  1987-06       Impact factor: 12.969

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