Literature DB >> 7622255

T-cell cytokine responses in human infection with Mycobacterium tuberculosis.

M Zhang1, Y Lin, D V Iyer, J Gong, J S Abrams, P F Barnes.   

Abstract

Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.

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Year:  1995        PMID： 7622255      PMCID： PMC173444          DOI： 10.1128/iai.63.8.3231-3234.1995

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  22 in total

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3.  Defining protective responses to pathogens: cytokine profiles in leprosy lesions.

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4.  Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions.

Authors:  Z Toossi; P Gogate; H Shiratsuchi; T Young; J J Ellner
Journal:  J Immunol       Date:  1995-01-01       Impact factor: 5.422

5.  Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.

Authors:  P F Barnes; V Mehra; B Rivoire; S J Fong; P J Brennan; M S Voegtline; P Minden; R A Houghten; B R Bloom; R L Modlin
Journal:  J Immunol       Date:  1992-03-15       Impact factor: 5.422

6.  Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

Authors:  D K Dalton; S Pitts-Meek; S Keshav; I S Figari; A Bradley; T A Stewart
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7.  Cytokine patterns in the pathogenesis of human leishmaniasis.

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8.  Patterns of cytokine production by mycobacterium-reactive human T-cell clones.

Authors:  P F Barnes; J S Abrams; S Lu; P A Sieling; T H Rea; R L Modlin
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

9.  Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

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10.  Selection of a human T helper type 1-like T cell subset by mycobacteria.

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Journal:  J Exp Med       Date:  1991-09-01       Impact factor: 14.307
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  81 in total

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2.  T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis.

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3.  CD69 expression on CD4+ T lymphocytes after in vitro stimulation with tuberculin is an indicator of immune sensitization against Mycobacterium tuberculosis antigens.

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5.  ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells.

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6.  Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice.

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7.  Serum protein profiling of smear-positive and smear-negative pulmonary tuberculosis using SELDI-TOF mass spectrometry.

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8.  Interleukin-10 downregulates Mycobacterium tuberculosis-induced Th1 responses and CTLA-4 expression.

Authors:  J H Gong; M Zhang; R L Modlin; P S Linsley; D Iyer; Y Lin; P F Barnes
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9.  Increased numbers of interleukin-12-producing cells in human tuberculosis.

Authors:  M E Munk; P Mayer; P Anding; K Feldmann; S H Kaufmann
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

10.  Monocytes and neutrophils from tuberculosis patients are insensitive to anti-inflammatory effects triggered by the prototypic formyl peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP).

Authors:  M Beigier-Bompadre; M Alemán; P Barrionuevo; M C Franco; C J Rubel; M Del C Sasiain; M S Palermo; E Abbate; M A Isturiz
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